61761-32-8 Usage
Description
5-Fluoronaphthalen-1-ol is an organic compound with the molecular formula C11H7FO. It is a fluorinated derivative of naphthalen-1-ol, featuring a hydroxyl group and a fluorine atom attached to the naphthalene ring. 5-Fluoronaphthalen-1-ol is known for its potential applications in the pharmaceutical industry due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
5-Fluoronaphthalen-1-ol is used as an intermediate in the preparation of duloxetine metabolites, which are important for the development of antidepressant medications. Its role in the synthesis process is crucial for creating effective treatments for various mental health disorders.
Used in Research and Development:
5-Fluoronaphthalen-1-ol is utilized in studies to evaluate the ability to inhibit radioligand binding to human serotonin, norepinephrine, and dopamine transporters. This application is significant for understanding the compound's potential as a therapeutic agent for neurological and psychiatric conditions, as it can help researchers determine its effectiveness in modulating neurotransmitter levels in the brain.
Check Digit Verification of cas no
The CAS Registry Mumber 61761-32-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,7,6 and 1 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 61761-32:
(7*6)+(6*1)+(5*7)+(4*6)+(3*1)+(2*3)+(1*2)=118
118 % 10 = 8
So 61761-32-8 is a valid CAS Registry Number.
61761-32-8Relevant articles and documents
A transition-metal-free synthesis of fluorinated naphthols
Hammann, Jeffrey M.,Unzner, Teresa A.,Magauer, Thomas
supporting information, p. 6733 - 6738 (2014/06/09)
Herein, we describe a transition-metal-free protocol for the conversion of simple 2-allyl-3-(trifluoromethyl)phenols into substituted 5-fluoronaphthalen-1- ols. The key events of this reaction include the selective activation of two C-F bonds and formatio
Synthesis and biological activity of some known and putative duloxetine metabolites
Kuo,Gillespie,Kulanthaivel,Lantz,Ma,Nelson,Threlkeld,Wheeler,Yi,Zmijewski
, p. 3481 - 3486 (2007/10/03)
Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine.
