617691-21-1Relevant articles and documents
Synthesis and Biological Evaluation of 3-(4-Substituted-phenyl)-N-hydroxy-2-propenamides, a New Class of Histone Deacetylase Inhibitors
Kim, Dae-Kee,Lee, Ju Young,Kim, Jae-Sun,Ryu, Je-Ho,Choi, Jin-Young,Lee, Jun Won,Im, Guang-Jin,Kim, Tae-Kon,Seo, Jung Woo,Park, Hyun-Ju,Yoo, Jakyung,Park, Jung-Hyun,Kim, Tae-You,Bang, Yung-Jue
, p. 5745 - 5751 (2007/10/03)
Inhibitors of histone deacetylases (HDACs) have been shown to induce differentiation and/or apoptosis of human tumor cells. Novel 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides have been prepared as a new class of HDAC inhibitors and evaluated for their antiproliferative activity and HDAC inhibitory activity. Incorporation of a 1,4-phenylene carboxamide linker, shown by 5, and a 4-(dimethylamino)phenyl or 4-(pyrrolidin-1-yl)phenyl group as a cap substructure generated highly potent hydroxamic acid-based HDAC inhibitors 5a and 5b.