617705-29-0Relevant academic research and scientific papers
Streamlined Symmetrical Total Synthesis of Disorazole B1and Design, Synthesis, and Biological Investigation of Disorazole Analogues
Aujay, Monette,Dherange, Balu D.,Gavrilyuk, Julia,Gu, Christine,Krieger, Johannes,Lin, Baiwei,Munneke, Stefan,Murhade, Ganesh M.,Nicolaou, K. C.,Purcell, James W.,Sandoval, Joseph,Sarvaiaya, Hetal,Subramanian, Parthasarathi,Vourloumis, Dionisios,Zhang, Zhaomei
, p. 15476 - 15487 (2020)
Taking advantage of the C2-symmetry of the antitumor naturally occurring disorazole B1 molecule, a symmetrical total synthesis was devised with a monomeric advanced intermediate as the key building block, whose three-step conversion to the natural product
Synthetic studies toward the disorazoles: Synthesis of a masked northern half of disorazole D1 and a cyclopropane analog of the masked northern half of disorazole A1
Haustedt, Lars Ole,Panicker, Sreeletha B.,Kleinert, Mike,Hartung, Ingo V.,Eggert, Ulrike,Niess, Barbara,Hoffmann
, p. 6967 - 6977 (2007/10/03)
The synthesis of a masked northern half of the natural product disorazole D1 and a cyclopropane analog of the masked northern half of disorazole A1 is described. The synthesis involves in both cases as key steps a Z-selective Wittig olefination and a Sonogashira cross-coupling reaction.
