617705-45-0Relevant academic research and scientific papers
Synthetic studies toward the disorazoles: Synthesis of a masked northern half of disorazole D1 and a cyclopropane analog of the masked northern half of disorazole A1
Haustedt, Lars Ole,Panicker, Sreeletha B.,Kleinert, Mike,Hartung, Ingo V.,Eggert, Ulrike,Niess, Barbara,Hoffmann
, p. 6967 - 6977 (2007/10/03)
The synthesis of a masked northern half of the natural product disorazole D1 and a cyclopropane analog of the masked northern half of disorazole A1 is described. The synthesis involves in both cases as key steps a Z-selective Wittig olefination and a Sonogashira cross-coupling reaction.
Toward the total synthesis of disorazole A1: Asymmetric synthesis of the masked northern half
Hartung, Ingo V.,Eggert, Ulrike,Haustedt, Lars Ole,Niess, Barbara,Schaefer, Peter M.,Hoffmann, H. Martin R.
, p. 1844 - 1850 (2007/10/03)
The stereoselective synthesis of the masked northern half of the antimitotic natural product disorazole A1 is described involving as key step a Z-selective Wittig olefination of a C1-C11 epoxy aldehyde with a C12-C19 phosphonium iodide.
