472979-46-7Relevant academic research and scientific papers
Synthetic studies toward the disorazoles: Synthesis of a masked northern half of disorazole D1 and a cyclopropane analog of the masked northern half of disorazole A1
Haustedt, Lars Ole,Panicker, Sreeletha B.,Kleinert, Mike,Hartung, Ingo V.,Eggert, Ulrike,Niess, Barbara,Hoffmann
, p. 6967 - 6977 (2007/10/03)
The synthesis of a masked northern half of the natural product disorazole D1 and a cyclopropane analog of the masked northern half of disorazole A1 is described. The synthesis involves in both cases as key steps a Z-selective Wittig olefination and a Sonogashira cross-coupling reaction.
Toward the total synthesis of disorazole A(1) and C(1): asymmetric synthesis of a masked southern segment.
Hartung, Ingo V,Niess, Barbara,Haustedt, Lars Ole,Hoffmann, H Martin R
, p. 3239 - 3242 (2007/10/03)
[reaction: see text] A highly convergent asymmetric synthesis of the masked southern segment of the antimitotic agent disorazole A(1) involves a Sonogashira coupling between a C1'-C10' enyne and a suitably protected C11'-C19' vinyl iodide. The central E,Z,Z-triene moiety is masked as a more stable ynediene.
