617706-61-3

Usage

Uses

Used in Pharmaceutical Industry:
617706-61-3 is used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of inflammatory conditions such as rheumatoid arthritis and osteoarthritis. It is utilized for its pain-relieving and anti-inflammatory properties, which are achieved by inhibiting the production of chemicals that cause these symptoms.
Additionally, the aluminium hydroxide component of Aloxiprin is used as a protective agent for the stomach lining, reducing the risk of gastrointestinal irritation and damage that can be associated with the use of aspirin alone. This dual-action makes Aloxiprin a suitable choice for patients requiring both pain relief and gastrointestinal protection. It is crucial to follow the guidance of healthcare professionals when using Aloxiprin due to potential side effects and interactions with other medications.

Upstream product

• 105309-59-9 tetrakis(4-bromophenyl)methane 
• 68-12-2 N,N-dimethyl-formamide 
• 630-76-2 tetraphenylmethane 
• 62-53-3 aniline 
• 76-83-5 trityl chloride 

Downstream Products

• 1246306-15-9 C₃₇H₄₄O₄ 

Relevant academic research and scientific papers

Room-temperature phosphorescence from a purely organic tetraphenylmethane derivative with formyl groups in both solution and crystalline states

Room-temperature phosphorescence of most purely organic compounds can hardly be observed in their solutions. Here, we report a tetraphenylmethane derivative with four aldehyde groups, which exhibits clear blue phosphorescence in its solution at room temperature. Furthermore, its crystal displays a nearly 7-fold higher phosphorescence quantum yield as compared to the solution. This journal is

Postsynthetic Functionalization of Three-Dimensional Covalent Organic Frameworks for Selective Extraction of Lanthanide Ions

Chemical functionalization of covalent organic frameworks (COFs) is critical for tuning their properties and broadening their potential applications. However, the introduction of functional groups, especially to three-dimensional (3D) COFs, still remains

Three-Dimensional Ionic Covalent Organic Frameworks for Rapid, Reversible, and Selective Ion Exchange

Covalent organic frameworks (COFs) have emerged as functional materials for various potential applications. However, the availability of three-dimensional (3D) COFs is still limited, and nearly all of them exhibit neutral porous skeletons. Here we report a general strategy to design porous positively charged 3D ionic COFs by incorporation of cationic monomers in the framework. The obtained 3D COFs are built of 3-fold interpenetrated diamond net and show impressive surface area and CO2 uptakes. The ion-exchange ability of 3D ionic COFs has been highlighted by reversible removal of nuclear waste model ions and excellent size-selective capture for anionic pollutants. This research thereby provides a new perspective to explore 3D COFs as a versatile type of ion-exchange materials.

A novel crystalline azine-linked three-dimensional covalent organic framework for CO2 capture and conversion

The targeted synthesis of three-dimensional covalent organic frameworks (3D COFs) is a great challenge, especially those synthesized by using a new kind of organic linkage. Herein, for the first time, a novel 3D azine-linked COF (3D-HNU5) has been synthesized and characterized. It is shown that the obtained 3D COF has a 2-fold interpenetrated diamond topology, and shows good chemical/thermal stability and a narrow pore size distribution, which exhibits excellent performance in the selective uptake of CO2 over N2. Moreover, the 3D-HNU5 is found to be an efficient catalyst for the cycloaddition of propargylic alcohols with CO2 into carbonates with excellent catalytic activity under mild conditions.

Two-Photon Absorption Properties and Structures of BODIPY and Its Dyad, Triad and Tetrad

A series consisting of a dyad, a triad and a tetrad containing either two, three and four BODIPY units, respectively, has been synthesized and fully characterized and compared to two mono-BODIPY analogs (used as references). The one- and two-photon photophysical properties have been measured and the X-ray structures of four of the BODIPY derivatives have been determined. In the 700–900 nm range, the two-photon absorption (TPA) cross sections range from 30 GM to 160 GM for these compounds.

Anhydrous proton conduction in porous organic networks

Solid electrolyte separators within fuel cells enable efficient charge transport and prevent a mass bypass between the two half cells. Hydrated systems, like Nafion, reach unprecedented proton conductivities at ambient temperatures, but the demanding humidity management prevents their use beyond 80 °C, hence limiting the efficiency of current polymer-based systems. As such, water free and chemically inert, solid materials with excellent conductivities between 100 °C and 200 °C, are of high interest. A promising approach is the incorporation of heavier amphoteric molecules into micro- and mesoporous frameworks. Stronger host-guest interactions allow for higher temperatures, while still maintaining sufficient mobility and efficient transport pathways. Here, we present a systematic study investigating the influence of porosity, framework topology and dimensionality as well as framework functionality and charge carrier uptake on the proton conductivity for six porous organic networks (PONs) loaded with imidazole via gas phase adsorption. The resulting materials were thoroughly characterized by multinuclear NMR and IR spectroscopy and physisorption as well as powder X-ray diffraction and DSC experiments, revealing homogeneous distribution of the amphoteric guests within the pore structure. Electrochemical impedance spectroscopy up to 130 °C revealed remarkable conductivities of up to 10?3 S cm?1 under anhydrous conditions. We found 3D networks to favour high imidazole loading leading to high proton conductivities based on the Grotthuss mechanism. In contrast, 2D networks showed a lower guest molecule uptake and thus lower proton conductivities, which were governed by vehicle transport. Additional acid/base functionalities within the frameworks seem to have a negative effect on the proton conduction.

Robust C-C bonded porous networks with chemically designed functionalities for improved CO2 capture from flue gas

Effective carbon dioxide (CO2) capture requires solid, porous sorbents with chemically and thermally stable frameworks. Herein, we report two new carbon-carbon bonded porous networks that were synthesized through metal-free Knoevenagel nitrile-aldol condensation, namely the covalent organic polymer, COP-156 and 157. COP-156, due to high specific surface area (650 m2/g) and easily interchangeable nitrile groups, was modified post-synthetically into free amine- or amidoxime-containing networks. The modified COP-156-amine showed fast and increased CO2 uptake under simulated moist flue gas conditions compared to the starting network and usual industrial CO2 solvents, reaching up to 7.8 wt % uptake at 40°C.