61777-25-1Relevant academic research and scientific papers
Catalytic asymmetric intramolecular homologation of ketones with α-diazoesters: Synthesis of cyclic α-Aryl/Alkyl β-ketoesters
Li, Wei,Tan, Fei,Hao, Xiaoyu,Wang, Gang,Tang, Yu,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming
supporting information, p. 1608 - 1611 (2015/01/30)
A catalytic asymmetric intramolecular homologation of simple ketones with α-diazoesters was firstly accomplished with a chiral N,N′-dioxide-Sc(OTf)3 complex. This method provides an efficient access to chiral cyclic α-aryl/alkyl β-ketoesters containing an all-carbon quaternary stereocenter. Under mild conditions, a variety of aryl- and alkyl-substituted ketone groups reacted with α-diazoester groups smoothly through an intramolecular addition/rearrangement process, producing the β-ketoesters in high yield and enantiomeric excess.
Environmentally friendly TPDS-mediated free radical ring expansion of α-haloalkyl cyclic β-keto esters
Sugi, Masaaki,Togo, Hideo
, p. 3171 - 3175 (2007/10/03)
Reactivities of tetraphenyldisilane (TPDS), tris(trimethylsilyl)silane, and tributyltin hydride in the radical ring expansion of α-haloalkyl cyclic β-keto esters were examined. Among these reagents, TPDS was found most effective for the preparation of medium-sized cyclic compounds in terms of yields and ring-expansion/reduction selectivity.
Synthesis of Diamagnetic Structural Analogues of Representative Doxyl, Proxyl, Piperidine, and Pyrroline Nitroxide Spin Labels
Keana, John F. W.,Seyedrezai, Seyed E.
, p. 347 - 352 (2007/10/02)
The objective of this work is the synthesis of diamagnetic close structural analogues of the more important doxyl 4, proxyl 5, piperidine 6, and pyrrolidine 7 nitroxide spin labels which are extensively used in biophysical investigations.Our approach is b
