61785-37-3Relevant academic research and scientific papers
Preparation of benzoyloxy benzophenone derivatives and their inhibitory effects of ICAM-1 expression
Kwon, Eun Mi,Kim, Cheol Gi,Goh, Ah Ra,Park, Jinseu,Jun, Jong-Gab
experimental part, p. 1939 - 1944 (2012/08/07)
Benzoyloxy benzophenone derivatives were prepared in 3 steps including DCC coupling, Fries rearrangement and esterification from benzoic acids in 24-89% total yields. Among the prepared 12 benzophenone analogues 1a-1l, the compound 1b having three chloro groups at the para position showed maximum inhibitory effects of ICAM-1 expression but, 1a which have no substituents at all showed no inhibitory activity. This study provides the evidences that benzoyloxy benzophenone derivative, 1b may exert its anti-inflammatory activity by suppressing IFN-γ-induced ICAM-1 expression.
Synthesis and crystal structure of [5-chloro-2-(4-nitrobenzyloxy)-phenyl]- (4-chloro-phenyl) methanone
Neetha,Venu,Sridhar,Shashidhara Prasad,Shashikanth
, p. 143 - 150 (2012/08/08)
The title compound, C20H13Cl2NO 4, crystallizes in the monoclinic crystal system and space group P21/n with cell parameters a = 9.434(2) A, b = 13.167(3) A, c = 15.087(4) A, β = 105.289(8)°, V = 1807.
Synthesis and crystal structure of [5-Chloro-2-(4-nitro-benzyloxy)-phenyl]- (4-chloro-phenyl) methanone
Neetha,Venu,Sridhar,Prasad, J. Shashidhara,Shashikanth
experimental part, p. 151 - 158 (2010/08/05)
The title compound, C20H13Cl2NO4, crystallizes in the monoclinic crystal system and space group P21/n with cell parameters a=9.434(2)A, b=13.167(3)A, c=15.087(4)A, β=105.289(8)°, V=1807.7(7)A3 for Z=4. The structure exhibits inter-molecular hydrogen bonds
Synthesis and crystallographic analysis of benzophenone derivatives-The potential anti-inflammatory agents
Venu,Shashikanth,Khanum,Naveen,Firdouse, Aiysha,Sridhar,Shashidhara Prasad
, p. 3505 - 3514 (2008/02/07)
Fries rearrangement of substituted phenyl benzoates 1a-j to substituted hydroxy benzophenones 2a-j was achieved in excellent yield. Further benzoylation of 2a-j to benzoyloxy benzophenones 4a-n, a benzophenone analogue was achieved in good yield. All the newly synthesized compounds were evaluated for their anti-inflammatory activity and were compared with standard drugs. Out of the compounds studied, the compounds 4c, 4e, 4g, 4h and 4k with chloro and methyl substituents at para position showed more potent activity than the standard drugs at all doses tested.
