61799-54-0

Upstream product

• 108-86-1 bromobenzene 
• 34645-17-5 acetic acid 3-methyl-1-methylene-but-2-enyl ester 
• 98746-90-8 ((Z)-2-Ethoxy-4-methyl-penta-1,4-dienyl)-benzene 
• 24397-32-8 1-phenylpenta-3,4-dien-2-one 
• 917-54-4 methyllithium 
• 121712-53-6 N-methoxy-N-methyl-3,3-dimethylacrylamide 
• 100-44-7 benzyl chloride 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 98746-72-6 tributyl{1-ethoxy-3-methylbut-3-enyl}tin 
• 100-52-7 benzaldehyde 
• 103-80-0 phenylacetyl chloride 
• 115-11-7 isobutene 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 2008-07-3 2-benzyl-1,3-benzoxazole 

Downstream Products

• 950672-88-5 2,2-dimethyl-4-oxo-5-phenyl-1-nitropentane 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2, 3-DIHYDRO-1H-PYRROLIZIN-5-YL ACETIC ACID AND ITS INTERMEDIATES

The present invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1H-pyrrolizin-5-yl acetic acid, in which the key intermediate, 5-Benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is obtained by the hydrogenation of 2,2-dimethyl-4-oxo-5-phenyl-nitropentane. The invention also relates to the preparation of the intermediates occurring in the above process.

Carbon-carbon bond forming reactions of η3-allyl iron tricarbonyl anions with carbon electrophiles

Reaction of the η3-allyl iron tricarbonyl anion, 1, with alkyl halides (RX, R = -CH3, -CH2Ph, -(CH2)3CH3, -CH(CH3)2,-CH2CH=CH2) followed by treat

Metallic Nickel-Mediated Synthesis of Ketones by the Reaction of Benzylic, Allylic, Vinylic, and Pentafluorophenyl Halides with Acid Halides

Metallic nickel was investigated as a convenient coupling reagent for the synthesis of ketones by the reaction of benzylic, allylic, vinylic, and pentafluorophenyl halides with acid halides at 85 deg C in glyme.A variety of benzylic ketones with functional groups including halogen, cyano, methoxycarbonyl, and hydroxycarbonyl groups were prepared in good yields by this method.The reaction was demonstrated to proceed via organonickel halide intermediates formed by the smooth oxidative addition of benzylic and acyl halides to metallic nickel, which were trapped with electron-deficient olefins. (?-Allyl)nickel halides, prepared in situ at 85 deg C from allylic halides and the nickel, also worked for the preparation of ketones.Vinylic and pentafluorophenyl halides but not alkyl halides reacted with acid halides to give the corresponding ketones in moderate yields.

RING OPENING OF BENZOXAZOLES WITH ALLYLIC GRIGNARD REAGENTS: SYNTHESIS OF N-DIALLYLALKYL-o-AMINOPHENOLS.

The title benzoxales 1a-d react cleanly with allylic Grignard reagents 2a-c undergoing ring opening to give good yields of N-diallyl-alkyl-o-aminophenols 3a-m.A plausible mechanism is discussed.

Arylation and 1-Alkenylation on α-Position of Ketones via Tributyltin Enolates Catalyzed by Palladium Complex

The reaction of tributyltin enolates, prepared from tributyltin methoxide and enol acetates in situ, with aryl and 1-alkenyl bromides in the presence of dichlorobis(tri-o-tolylphosphine)palladium was found to give α-aryl and α-(1-alkenyl) ketones, respectively, in good yields with essentially complete retention of the enol acetate regiochemistry.