618-61-1

Basic information

• Product Name: 3-METHYL-5-NITRO ANILINE
• Synonyms: SALOR-INT L170186-1EA;3-METHYL-5-NITRO ANILINE;3-Methyl-5-notroaniline;3-Nitro-5-methylaniline;3-Amino-5-nitrotoluene
• CAS NO: 618-61-1
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• Mol File: 618-61-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 324.2 °C at 760 mmHg
• Flash Point: 149.8 °C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 0.00025mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.65±0.10(Predicted)
• CAS DataBase Reference: 3-METHYL-5-NITRO ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-5-NITRO ANILINE(618-61-1)
• EPA Substance Registry System: 3-METHYL-5-NITRO ANILINE(618-61-1)

Safety Data

• Hazardous Substances Data: 618-61-1(Hazardous Substances Data)

Usage

Uses

3-Methyl-5-nitroaniline is used in the synthesis of potent BMX inhibitors responsible for hampering ATP catalysis.

InChI:InChI=1/C7H8N2O2/c1-5-2-6(8)4-7(3-5)9(10)11/h2-4H,8H2,1H3

Upstream product

• 618-85-9 3,5-dinitrotoluene 
• 60546-37-4 4-methyl-2,6-dinitro-phenetole 
• 19578-70-2 benzyl 2-methylphenyl ether 
• 29506-83-0 (2-methyl-4,6-dinitro-phenyl)-(4-nitro-benzyl)-ether 
• 29507-41-3 2-methyl-4,6-dinitro-phenetole 
• 614-71-1 2-ethoxytoluene 
• 622-60-6 1-ethoxy-4-methylbenzene 
• 6393-42-6 4-methyl-2,6-dinitroaniline 
• 1208074-91-2 2-ethoxy-1-methyl-3-nitrobenzene 
• 7477-94-3 2-methyl-4,6-dinitroaniline 

Downstream Products

• 65542-47-4 3-Nitrotoluol-5-sulfonamid 
• 1259373-50-6 (3S)-N-(3-((2-chloro-5-fluoropyrimidin-4-yl)amino)-5-methylcyclohexyl)-3-fluoropyrrolidine-1-carboxamide 
• 94384-64-2 5-methylcyclohexane-1,3-diamine 
• 94384-64-2 5-methylcyclohexane-1,3-diamine 
• 108-71-4 3,5-diaminotoluene 
• 69112-72-7 acetic acid-(3-methyl-5-nitro-anilide) 
• 76619-89-1 3-amino-5-methylphenol 
• 89444-76-8 2,4,6-tribromo-3-methyl-5-nitro-phenol 
• 602-97-1 3,5-dihydroxy-2,4,6-trinitrotoluene 
• 96461-04-0 3-benzenesulfonyl-5-nitro-benzoic acid 
• 861794-61-8 acetic acid-(3,4-dinitro-5-methyl-anilide) 
• 861297-21-4 acetic acid-(5-methyl-2,3-dinitro-anilide) 
• 70343-07-6 2,3-dinitro-5-methylaniline 
• 70343-08-7 3,4-dinitro-5-methylaniline 

Relevant articles and documents

The Kinetics of the Reactions of Picryl Chloride with Some Substituted Anilines. Part 5.

Arrhenius parameters have been measured for the reactions of picryl chloride with the following substituted anilines in acetonitrile: 3-amino- and 3-methyl-aniline, 3-amino-5-nitroaniline, 3-fluoro-5-methylsulphonylaniline, 3-X-5-methylanilines (X=NO2, OMe, CH3, F, Cl, Br, or I) and 3,5-X2-anilines (X = F, Cl, Br, or I).A total of 33 3,5-disubstituted anilines have now been examined for the additivity of substituent effects on the free energy of activation, and it has been shown that with the exception of 3-amino-5-nitroaniline this hypothesis reproduces experimental rate constants within a factor of 2.A rationalization is proposed for the deviations that occur in some cases when more stringent criteria of additivity are used.