618098-47-8

Usage

Uses

Used in Organic Synthesis:
1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazole-4-carbaldehyde is used as a reagent in organic synthesis for the creation of other compounds. Its aldehyde group allows for a wide range of chemical reactions, making it a versatile building block in the synthesis of various organic molecules.
Used in Pharmaceutical Research and Drug Development:
Due to its unique structure and properties, 1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazole-4-carbaldehyde may have applications in pharmaceutical research and the development of drugs. Its potential use in this field could be attributed to its ability to interact with biological targets or serve as a precursor to more complex molecules with therapeutic potential.
Used in Chemical Reactions:
1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazole-4-carbaldehyde is also used as a building block for other compounds in various chemical reactions. Its presence in these reactions can lead to the formation of new molecules with different properties and applications, further expanding the utility of 1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazole-4-carbaldehyde in the chemical industry.

Upstream product

• 386272-18-0 1-(4-chlorophenyl)-2-(1-p-tolylethylidene)hydrazine 
• 68-12-2 N,N-dimethyl-formamide 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 

Downstream Products

• 1020238-17-8 C₁₉H₁₇ClN₂O₂ 
• 1311965-69-1 C₁₉H₁₅ClN₂O₂ 
• 1443021-79-1 4-chloro-N-((1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)methylene)aniline 
• 1443021-78-0 N-((1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)methylene)-4-methoxyaniline 
• 1443021-77-9 N-((1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)methylene)aniline 
• 1443022-02-3 1-(4-chlorophenyl)-4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazole 
• 1443022-01-2 1-(4-chlorophenyl)-4-(5-(4-chlorophenyl)-2-(4-fluorophenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazole 
• 1443021-94-0 4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-methoxyphenyl)butan-1,4-dione 
• 1443021-93-9 4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione 

Relevant academic research and scientific papers

Novel pyrazole-clubbed thiophene derivatives via Gewald synthesis as antibacterial and anti-inflammatory agents

The aim of this study was to synthesize newer potent Schiff bases by condensing 2-amino-5-(2,4-dichlorophenyl)thiophene-3-carbonitrile and 1,3-disubstituted-1H-pyrazole-4-carbaldehydes, and to investigate their biological activity. The compounds were synthesized via Gewald synthesis and characterized by spectral data and elemental analyses. They were screened for their in vitro antibacterial and anti-inflammatory activities. The synthesized compounds were also evaluated for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using the microplate Alamar Blue assay. Compounds 8b, 8c, 8f, 8g, 8k, 8n, and 8o showed promising antibacterial activity. The interactions between the substituted pyrazoles and bovine protein showed promising anti-inflammatory activity. The experimental results revealed compound 8a as a promising antitubercular agent. Hemolytic assays confirmed that the compounds are nontoxic, with percentage hemolysis ranging from 3.6 to 20.1, at a concentration of 1 mg/ml. The results suggest that the pyrazole ring and the substitution pattern on the heterocyclic moiety have an effect on the bioactivity.

Antitubercular and antimicrobial activity of nh4vo3 promoted 1,4-dihydropyridine incorporated 1,3,4-Trisubstituted pyrazole

Background: A new series of pyrazole containing 1,4-dihydropyridine derivatives 5a-i and 6a-i were synthesized from substituted acetylated aryls and substituted phenylhydrazine by the multistep reaction. Method: The target compounds 1,4-dihydropyridine de

1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: Synthesis, characterization and its biological studies

A new series 3-{2-[N′-(1,3-disubstituted-1H-pyrazol-4-yl-methylene)-hydrazino]-thiazol-4-yl}-chromen-2-one (10a-l) was synthesized by a multi-step reaction. All the synthesized compounds were characterized by IR, NMR, and mass spectral studies, followed by elemental analysis. The newly synthesized thiazole compounds were screened for their in vitro antibacterial and antifungal studies against various microorganisms. Antimicrobial studies carried out by the well diffusion method, showed a very good zone of inhibition for both bacteria (at a range of 20-50 mm diameter) and fungi (at a range of 10-30 mm diameter). Minimum Inhibitory Concentration (MIC) required for the 100% inhibition of bacteria and fungi was found to be as low as 15.6 μg ml-1 for a few of the synthesized compounds.

Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents

Some novel 1,3,4-trisubstituted pyrazoles were synthesized and screened for their anti-inflammatory and analgesic activities as well as their ulcerogenic liability. They showed anti-inflammatory and analgesic activities with better GIT tolerance than the standard drug phenylbutazone. In addition, IC 50 values for 5e and 8e were recorded. Compound 5e was found to be the most active one as anti-inflammatory and analgesic agent. On the other hand, COX-1/COX-2 isozyme selectivity was also done which showed equal inhibition to both isoforms.

Synthesis of 3-(1, 3-diphenyl-1H-pyrazol-4-yl) propanoic acids using diimide reduction

Pyrazole-1H-4-yl-acrylic acids (3a-j) were prepared from pyrazole-1H-4-carbaldehydes which in turn were prepared by the Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j). The reaction of pyrazole-1H- 4-yl-acrylic acids to 3-(1, 3-diphenyl-1H

Synthesis and biological evaluation of some novel 3-(1,3-diphenyl-1H- pyrazol-4-yl) propanoic acids

Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j) afforded 1,3-diphenyl-1 W-pyrazole-4-carbaldehydes (2a-j). Condensation of (2a-j) with malonic acid gave 3-(1,3-diphenyl-1/-/-pyrazol-4-yl) acrylic acids (3a-j. Reduction of (3a-j) gave 3-(1,