6181-26-6

Basic information

• Product Name: 1,1,1-TRICHLORO-4-PHENYL-BUT-3-YN-2-OL
• Synonyms: 1,1,1-TRICHLORO-4-PHENYL-BUT-3-YN-2-OL
• CAS NO: 6181-26-6
• Molecular Formula: C₁₀H₇Cl₃O
• Molecular Weight: 249.52098
• Mol File: 6181-26-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,1,1-TRICHLORO-4-PHENYL-BUT-3-YN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-TRICHLORO-4-PHENYL-BUT-3-YN-2-OL(6181-26-6)
• EPA Substance Registry System: 1,1,1-TRICHLORO-4-PHENYL-BUT-3-YN-2-OL(6181-26-6)

Safety Data

• Hazardous Substances Data: 6181-26-6(Hazardous Substances Data)

Usage

Type

Synthetic chemical compound

Usage

Widely used as an antibacterial and antifungal agent

Application

Personal care products (soaps, toothpaste, deodorants) and preservative in household products (textiles, plastics)

Health Concerns

Potential negative effects on human health

Environmental Impact

Disrupts hormones, contributes to antibiotic resistance, and harms aquatic organisms

Regulation

Subject to increased scrutiny and regulation in recent years

Bans and Restrictions

Some countries and companies have banned or restricted its use in consumer products

Upstream product

• 6738-06-3 phenylethynylmagnesium bromide 
• 75-87-6 chloral 
• 1004-22-4 (phenylethynyl)sodium 
• 52137-73-2 Trimethyl-(3-phenyl-1-trichloromethyl-prop-2-ynyloxy)-silane 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 536-74-3 phenylacetylene 
• 1719-19-3 2-Methyl-4-phenyl-3-butyn-2-ol 
• 2579-22-8 Phenylpropargyl aldehyde 
• 76-03-9 trichloroacetic acid 
• 67-66-3 chloroform 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 

Downstream Products

• 139040-41-8 (R)-4-phenyl-1,1,1-trichloro-2-butanol 
• 780760-99-8 (S)-4-phenyl-1,1,1-trichloro-2-butanol 
• 4009-22-7 agropyrene 
• 10508-66-4 hexa-1,3-diyn-1-ylbenzene 
• 36038-38-7 1,1,2-Trichlor-4-phenyl-1-buten-3-in 
• 91735-12-5 1,1,5-Triphenyl-2,4-pentadiin-1-ol 
• 91735-15-8 5-Phenyl-2,4-pentadiinsaeureethylester 
• 38177-56-9 trimethyl(4-phenylbuta-1,3-diyn-1-yl)silane 
• 7608-31-3 Ph₂PC*C-C*CPh 
• 36038-39-8 1.1.2-Trichlor-3.4-dibrom-4-phenyl-butadien-(1.3) 
• 847363-75-1 1-trichloromethyl-3-phenyl-2-propyn-1-ol mesylate 
• 36038-37-6 3,4,4,4-Tetrachlor-1-phenyl-1-butin 
• 847363-82-0 1,1-dichloro-4-(2-methoxyphenyl)amino-4-phenylbut-3-en-2-one 
• 847363-81-9 1,1-dichloro-4-(4-methoxyphenyl)amino-4-phenylbut-3-en-2-one 

Relevant articles and documents

One-pot synthesis of trichloromethyl carbinols from primary alcohols

Versatile trichloromethyl carbinols can be prepared in one pot from primary alcohols by treatment with Dess-Martin periodinane (DMP) in CHCl3 followed by introduction of commercially available 1,5,7-triazabicyclo[4.4.0] dec-5-ene (TBD). A modification of the method was used to convert chiral primary alcohol (R)-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol to the corresponding trichloromethyl carbinol with complete stereochemical fidelity, despite the reactant proceeding through a base-sensitive aldehyde intermediate.

First Meerwein-Ponndorf-Verley alkynylation: Nonorganometallic way for carbonyl alkylations [16]

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New syntheses of trichloromethyl functional alcohols. Studies of tranquilizing properties

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