6181-26-6

Usage

Type

Synthetic chemical compound

Usage

Widely used as an antibacterial and antifungal agent

Application

Personal care products (soaps, toothpaste, deodorants) and preservative in household products (textiles, plastics)

Health Concerns

Potential negative effects on human health

Environmental Impact

Disrupts hormones, contributes to antibiotic resistance, and harms aquatic organisms

Regulation

Subject to increased scrutiny and regulation in recent years

Bans and Restrictions

Some countries and companies have banned or restricted its use in consumer products

Upstream product

• 6738-06-3 phenylethynylmagnesium bromide 
• 75-87-6 chloral 
• 1004-22-4 (phenylethynyl)sodium 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 536-74-3 phenylacetylene 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 67-66-3 chloroform 
• 2579-22-8 Phenylpropargyl aldehyde 
• 76-03-9 trichloroacetic acid 
• 1719-19-3 2-Methyl-4-phenyl-3-butyn-2-ol 
• 52137-73-2 Trimethyl-(3-phenyl-1-trichloromethyl-prop-2-ynyloxy)-silane 

Downstream Products

• 36038-37-6 3,4,4,4-Tetrachlor-1-phenyl-1-butin 
• 139040-41-8 (R)-4-phenyl-1,1,1-trichloro-2-butanol 
• 780760-99-8 (S)-4-phenyl-1,1,1-trichloro-2-butanol 
• 847363-75-1 1-trichloromethyl-3-phenyl-2-propyn-1-ol mesylate 
• 847363-80-8 1,1-dichloro-4-phenylamino-4-phenylbut-3-en-2-one 
• 847363-83-1 1,1-dichloro-4-(4-methylphenyl)amino-4-phenylbut-3-en-2-one 
• 847363-81-9 1,1-dichloro-4-(4-methoxyphenyl)amino-4-phenylbut-3-en-2-one 
• 847363-82-0 1,1-dichloro-4-(2-methoxyphenyl)amino-4-phenylbut-3-en-2-one 
• 4009-22-7 agropyrene 
• 10508-66-4 hexa-1,3-diyn-1-ylbenzene 
• 36038-38-7 1,1,2-Trichlor-4-phenyl-1-buten-3-in 
• 91735-12-5 1,1,5-Triphenyl-2,4-pentadiin-1-ol 

Relevant academic research and scientific papers

One-pot synthesis of trichloromethyl carbinols from primary alcohols

Versatile trichloromethyl carbinols can be prepared in one pot from primary alcohols by treatment with Dess-Martin periodinane (DMP) in CHCl3 followed by introduction of commercially available 1,5,7-triazabicyclo[4.4.0] dec-5-ene (TBD). A modification of the method was used to convert chiral primary alcohol (R)-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol to the corresponding trichloromethyl carbinol with complete stereochemical fidelity, despite the reactant proceeding through a base-sensitive aldehyde intermediate.

Addition of amines to the triple bond in α, α α-trichloromethylpropargyl mesylate: Synthesis of α,α- dichloromethylenaminones and preparation of 2-phenyl-4-dichloromethylquinolines

Addition of amines to the triple bond in α,α,α,- trichloromethylpropargyl mesylate to give α,α- dichloromethylenaminones and its use in the preparation of 2-phenyl-4- dichloromethylquinolines in good yields are reported.

Polyynes, IV. Synthesis of Unsymmetrically Substituted Diacetylenes via 1,1,2-Trichloro-1-alken-3-ynes

Phenylacetylene (1a) and 1-hexyne (1b) react with bromo(ethyl)magnesium and trichloroacetaldehyde to the corresponding acetylenic carbinols 2.Successive treatment of 2 with phosphorus pentachloride and triethylamine furnishes via the 1,1,1,2-tetrachloro-3