618101-88-5

Usage

Chemical class

Pyrazole carboxylic acids

Structure

Contains a pyrazole ring, a bromo-phenyl substitution at the 2-position, a methyl group at the 5-position, and a carboxylic acid group at the 3-position

Usage

Building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Versatility

Unique structure and functional groups make it a valuable intermediate in organic synthesis and drug discovery research

InChI:InChI=1/C11H9BrN2O2/c1-7-6-10(11(15)16)14(13-7)9-4-2-8(12)3-5-9/h2-6H,1H3,(H,15,16)

Upstream product

• 615-79-2 ethyl 2,4-diketopentanoate 
• 589-21-9 (4-bromophenyl)hydrazine 
• 82874-96-2 2-methoxyimino-4-oxo-pentaneperoxoic acid ethyl ester 
• 385831-39-0 ethyl 1-(4-bromophenyl)-3-methyl-1H-pyrazole-5-carboxylate 
• 5699-58-1 2,4-dioxo-pentanoic acid 

Downstream Products

• 1448684-69-2 2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(4-bromophenyl)-3-methyl-1H-pyrazole-5-carboxylate 

Relevant academic research and scientific papers

Hydroxamic Acid-Based Histone Deacetylase (HDAC) inhibitors bearing a pyrazole scaffold and a cinnamoyl linker

Genetic abnormalities have been conventionally considered as hallmarks of cancer. However, recent studies have demonstrated that epigenetic mechanisms are also implicated in the insurgence and development of cancer. Patterns of the epigenetic component in

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Synthesis and insecticidal evaluation of aryl pyrazole 5-fluorouracil compounds

Twenty eight aryl pyrazole derivatives containing 5-fluorouracil were designed and synthesised via the key intermediate 1-aryl-3-methyl-1H-pyrazole-5- carboxylic acid. The structures of target compounds were confirmed by 1H NMR, FT-IR, EA and t