618113-62-5

Basic information

• Product Name: 2-Iodomethyl-1,2,3,4-tetrahydro-quinoline
• CAS NO: 618113-62-5
• Molecular Weight: 273.116
• Mol File: 618113-62-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Iodomethyl-1,2,3,4-tetrahydro-quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodomethyl-1,2,3,4-tetrahydro-quinoline(618113-62-5)
• EPA Substance Registry System: 2-Iodomethyl-1,2,3,4-tetrahydro-quinoline(618113-62-5)

Safety Data

• Hazardous Substances Data: 618113-62-5(Hazardous Substances Data)

Upstream product

• 63430-96-6 1,2,3,4-tetrahydroquinolin-2-ylmethanol 
• 63430-79-5 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester 
• 46185-24-4 1,2,3,4-tetrahydroquinoline-2-carboxylic acid 
• 93-10-7 quinoline-2-carboxylic acid 
• 618113-49-8 carbonic acid allyl ester 2-allyloxycarbonylaminobenzyl ester 
• 618113-45-4 (2-chloromethylphenyl)carbamic acid allyl ester 
• 125447-80-5 1H,3H,3aH,4H,5H-[1,3]oxazolo[3,4-a]quinolin-1-one 
• 345201-68-5 prop-2-en-1-yl N-[2-(hydroxymethyl)phenyl]carbamate 
• 17374-20-8 1,4-dihydro-benzo[d][1,3]oxazine-2-thione 
• 5344-90-1 2-Aminobenzyl alcohol 

Downstream Products

• 185854-45-9 2-(1,2,3,4-tetrahydroquinolin-2-yl)acetic acid 
• 150533-87-2 6-bromo-5-<(methoxycarbonyl)methyl>-6,7-dihydro-1H,5H-pyrido<1,2,3-de>quinoxaline-2,3-dione 

Relevant articles and documents

Enzymatic resolution of 2-substituted tetrahydroquinolines. Convenient approaches to tricyclic quinoxalinediones as potent NMDA-glycine antagonists

Two approaches leading to the enantiomerically pure tricyclic quinoxalinedione class of NMDA-glycine antagonists using enzymatic resolutions are described. An intermediate, racemic methyl 1,2,3,4- tetrahydroquinoline-2-carboxylate 3, was resolved to (S)-3

Tricyclic Quinoxalinediones: 5,6-Dihydro-1H-pyrroloquinoxaline-2,3-diones and 6,7-Dihydro-1H,5H-pyridoquinoxaline-2,3-diones as Potent Antagonists for the Glycine Binding Site of the NMDA Receptor

A series of tricyclic quinoxalinediones, 5,6-dihydro-1H-pyrroloquinoxaline-2,3-diones and 6,7-dihydro-1H,5H-pyridoquinoxaline-2,3-diones, were synthesized and was evaluated for their affinity for the glycine binding site of the NMDA receptor using a -5,7-dichlorokynurenic acid binding assay.The six-membered ring-fused tricyclic quinoxalinedione 18g (Ki = 9.9 nM) displayed high affinity for the glycine site.The anilide derivative 20g (Ki = 2.6 nM) was 4-fold more potent than 18g and as potent as L-689,560, one of the most potent glycineantagonists so far prepared.Although the carboxylic acid derivative of the corresponding five-membered ring-fused tricyclic quinoxalinedione 18e (Ki = 7.3 nM) had affinity comparable to that of 18g, the anilide derivative 20e largely decreased in the affinity in contrast to 20g.Enantiomers 23g, 24g, 25g, and 26g were prepared and tested.Only the S enantiomer 25g (Ki = 0.96 nM) retained the affinity among the anilide derivatives, whereas both enantiomers 23g (Ki = 2.3 nM) and 24g (Ki = 9.6 nM) were active among the carboxylic acid derivatives.The origin of the high affinity of carboxylic acid derivatives such as 18e and 18g would be a charge-charge interaction between the anionic carboxylate residues of the compounds and the cationic proton-donor site in the receptor.