6182-84-9

Basic information

• Product Name: N-tert-butyl-N~2~-(4-chlorophenyl)-N~2~-(methylsulfonyl)glycinamide
• Synonyms: acetamide, 2-[(4-chlorophenyl)(methylsulfonyl)amino]-N-(1,1-dimethylethyl)-
• CAS NO: 6182-84-9
• Molecular Formula: C₁₀H₁₁ClOS
• Molecular Weight: 318.8196
• Mol File: 6182-84-9.mol
• Article Data: 3

Chemical Properties

• Density: 1.28g/cm³
• Refractive Index: 1.559
• CAS DataBase Reference: N-tert-butyl-N~2~-(4-chlorophenyl)-N~2~-(methylsulfonyl)glycinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyl-N~2~-(4-chlorophenyl)-N~2~-(methylsulfonyl)glycinamide(6182-84-9)
• EPA Substance Registry System: N-tert-butyl-N~2~-(4-chlorophenyl)-N~2~-(methylsulfonyl)glycinamide(6182-84-9)

Safety Data

• Hazardous Substances Data: 6182-84-9(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 6182-85-0 2-(benzylthio)propanoic acid 

Downstream Products

• 33179-00-9 S-Benzyl-(2R)-mercaptopropionsaeure-methylester 
• 21793-76-0 (R)-2-(benzylthio)propanoic acid 
• 33767-29-2 α-Benzylthio-propionsaeuremethylester 
• 32363-02-3 S-Ethyl-2-(benzylthio)-thiopropionat 
• 87122-97-2 N,N-dimethyl-2-(benzylthio)propanamide 
• 87122-95-0 2-(benzylthio)propanamide 
• 65002-19-9 S-benzyl-N-(S-benzyl-2-mercaptopropanoyl)-L-cysteine 
• 52414-72-9 ethyl alpha-(benzylmercapto)-propionate 

Relevant articles and documents

Trichosporon beigelli esterase (TBE): A versatile esterase for the resolution of economically important racemates

A hydrolase producing strain Trichosporon beigelli esterase (TBE) isolated from local cottage cheese in its native form has displayed versatility and high efficacy in the kinetic resolution of a wide range of economically important substrates, which include racemic secondary alcohols, such as 1-(6-methoxy-2-naphthyl)ethanol (E ～ 316), 1-(3,4-methylenedioxyphenyl) ethanol and pentanol (E ～ 180 and 156 resp.), and alkyl esters of carboxylic acids such as ibuprofen (E ～ 340), 2-(benzylthio)propanoic acid (E ～ 1000). In other substrates such as in the primary alcohol 2-(6-methoxy-2- naphthyl)propan-1-ol and carboxylic acids such as 2-(5-bromo-6-methoxy-2- naphthyl)propanoic acid, 2-(2-naphthyloxy)propanoic acid, and substituted 2-thiopropanoic acids, it displayed moderate to low selectivity. Commercial lipases such as CCL, PPL, and PSL were also used in the resolution of the substrates for comparative studies.

Mass Spectrometry of 2-Alkylthio-2-methylpropanoic Acids and Their Esters and Amides. Structural and Steric Effects on the McLafferty Rearrangement

The electron ionization mass spectra (MS) of S-methylated derivatives of N-(2-mercapto-2-methylpropanoyl)-L-cysteine and 2-alkylthio-2-methylpropanoic acids, as well as their esters and amides, were examined.Use of the deuterium labeling technique and accurate mass measurement supported the proposed fragmentation pathways.Extensive loss of CH2S from a molecular ion by the McLafferty rearrangementof a primary hydrogen is important in the MS of S-methyl compounds of amide derivatives.It was demonstrated that the intensity of the rearrangement ion decreases in the order of amide, ester, and acid, and in the case if amides the reaarangement is suppressed by the nonbonded interaction between methyl groups on the α carbon and the amide nitrogen.Keywords-N-(2-mercapto-2-methylpropanoyl)-L-cysteine; 2-alkylthio-2-methylpropanoic acid and methyl ester; 2-alkylthio-2-methylpropanamide; electron impact mass spectrometry; McLafferty rearrangement; steric interaction