61820-97-1

Basic information

• Product Name: 2-[(4-CHLOROPHENYL)SULFONYL]-1-(4-METHOXYPHENYL)-1-ETHANONE
• Synonyms: 2-[(4-CHLOROPHENYL)SULFONYL]-1-(4-METHOXYPHENYL)-1-ETHANONE;2-(4-chlorobenzenesulfonyl)-1-(4-methoxyphenyl)ethan-1-one
• CAS NO: 61820-97-1
• Molecular Formula: C₁₅H₁₃ClO₄S
• Molecular Weight: 324.78
• Mol File: 61820-97-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 169 °C
• Boiling Point: 544.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.336±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-[(4-CHLOROPHENYL)SULFONYL]-1-(4-METHOXYPHENYL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-CHLOROPHENYL)SULFONYL]-1-(4-METHOXYPHENYL)-1-ETHANONE(61820-97-1)
• EPA Substance Registry System: 2-[(4-CHLOROPHENYL)SULFONYL]-1-(4-METHOXYPHENYL)-1-ETHANONE(61820-97-1)

Safety Data

• Hazardous Substances Data: 61820-97-1(Hazardous Substances Data)

Upstream product

• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 768-60-5 4-methoxyphenylacetylen 
• 2751-25-9 p-chlorophenylsulfonyl hydrazide 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 61821-17-8 2-(4-Chloro-benzenesulfonyl)-2-methoxy-1-(4-methoxy-phenyl)-ethanone 
• 61821-03-2 2-(4-Chloro-benzenesulfonyl)-2-diazo-1-(4-methoxy-phenyl)-ethanone 

Relevant articles and documents

One-pot synthesis of chiral β-hydroxysulfones from alkynes: Via aerobic oxysulfonylation and asymmetric reduction in MeOH/H2O

A highly enantioselective synthesis of β-hydroxysulfones from inexpensive and readily available terminal alkynes and sodium sulfinates via a consecutive one-pot reaction in an aqueous medium under mild conditions is described. The intermediates, β-keto sulfones, generated from an aerobic oxysulfonylation of terminal alkynes and sodium sulfinates catalyzed by an iron salt in MeOH/H2O (v : v = 3 : 1) at 50 °C, were subsequently reduced by a Ru-catalyzed asymmetric transfer hydrogenation with HCOONa as a hydrogen source. A variety of chiral β-hydroxysulfones were obtained in good yields and up to 99.9% ee values. This one-pot process could be easily scaled up for gram-scale synthesis.