61820-97-1Relevant academic research and scientific papers
One-pot synthesis of chiral β-hydroxysulfones from alkynes: Via aerobic oxysulfonylation and asymmetric reduction in MeOH/H2O
Cui, Peng,Liu, Qixing,Wang, Juan,Liu, Huan,Zhou, Haifeng
supporting information, p. 634 - 639 (2019/02/14)
A highly enantioselective synthesis of β-hydroxysulfones from inexpensive and readily available terminal alkynes and sodium sulfinates via a consecutive one-pot reaction in an aqueous medium under mild conditions is described. The intermediates, β-keto sulfones, generated from an aerobic oxysulfonylation of terminal alkynes and sodium sulfinates catalyzed by an iron salt in MeOH/H2O (v : v = 3 : 1) at 50 °C, were subsequently reduced by a Ru-catalyzed asymmetric transfer hydrogenation with HCOONa as a hydrogen source. A variety of chiral β-hydroxysulfones were obtained in good yields and up to 99.9% ee values. This one-pot process could be easily scaled up for gram-scale synthesis.
Visible-light-promoted syntheses of β-keto sulfones from alkynes and sulfonylhydrazides
Cai, Shunyou,Chen, Danling,Xu, Yaohui,Weng, Wen,Li, Lihuang,Zhang, Ruijie,Huang, Mingqiang
supporting information, p. 4205 - 4209 (2016/05/24)
A variety of functionalized β-keto sulfones were smoothly prepared through oxysulfonylation of commercially available alkynes with sulfonylhydrazides under the synergistic interactions of visible light irradiation, Ru(bpy)3Cl2 photocatalyst, oxygen, KI, and NaOAc basic additive under very mild reaction conditions.
