2751-25-9

Usage

Uses

Used in Pharmaceutical Industry:
4-chlorobenzenesulfonohydrazide is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs and improving the efficacy and safety of existing medications.
Used in Agrochemical Industry:
4-chlorobenzenesulfonohydrazide is used as a precursor in the synthesis of agrochemicals, aiding in the creation of effective and environmentally friendly pesticides and other agricultural products.
Used in Dye Production:
4-chlorobenzenesulfonohydrazide is used as a component in the production of dyes, enhancing the color quality and performance of various dye products.
Used in UV Stabilizer Production:
4-chlorobenzenesulfonohydrazide is used in the production of UV stabilizers, which protect materials from the damaging effects of ultraviolet radiation and extend their lifespan.
Used in Chemical Research:
4-chlorobenzenesulfonohydrazide is used as a versatile reagent for the preparation of hydrazone derivatives, facilitating research and development in the chemical industry.
Used in Electrochemical Sensor Development:
4-chlorobenzenesulfonohydrazide has been utilized in the development of electrochemical sensors for the detection of organic compounds, improving the sensitivity and selectivity of analytical methods.

Upstream product

• 98-66-8 4-chloro-benzenesulfonic acid 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 115273-43-3 4-chloro-benzenesulfonic acid-(N'-ξ-D-ribopyranosyl-hydrazide) 
• 108752-89-2 4-chloro-benzenesulfonic acid-(N'-ξ-D-glucopyranosyl-hydrazide) 
• 4547-68-6 p-chlorobenzenesulfonyl azide 
• 92022-89-4 4-chloro-benzenesulfonic acid benzylidenehydrazide 
• 89665-53-2 4-chloro-benzenesulfonic acid isopropylidenehydrazide 
• 18405-28-2 D-erythro-Pentulose-<4-chlor-benzolsulfonylhydrazon> 
• 7085-13-4 4-Aethoxycarbonylmethyl-1-<4-chlor-benzolsulfonyl>-semicarbazid 
• 344876-41-1 C₁₇H₂₅ClN₂O₂S 
• 85318-93-0 C₁₆H₂₁ClN₂O₂S 
• 93061-77-9 C₁₂H₁₀ClN₃O₂S*ClH 
• 125912-01-8 C₂₁H₁₅ClN₄O₄S 
• 219711-55-4 2-(4-chloro-benzenesulfonyl)-6-hydroxy-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers

In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy and LC-MS spectrometry, besides elemental analysis. The compou

Electrochemical fluorosulfonylation of alkenes to access vicinal fluorinated sulfones derivatives

Herein, we report a practical and efficient fluorosulfonylation of the various alkenes with sulfonyl radical sources (RSO2NHNH2) and Et3N·3HF as cost-effective fluorination reagents under mild conditions. Remarkably, this

Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.

Electrochemical heterodifunctionalization of α-CF3alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols

An unprecedented electrochemical heterodifunctionalization of α-CF3alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcohols were assembled under mild conditions. Electrochemically-driven oxidative 1,2-difunctionlization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly.

Electrochemical fluorosulfonylation of styrenes

An environmentally friendly and efficient electrochemical fluorosulfonylation of styrenes has been developed. With the use of sulfonylhydrazides and triethylamine trihydrofluoride, a diverse array of β-fluorosulfones could be readily obtained. This reaction features mild conditions and a broad substrate scope, which could also be conveniently extended to a gram-scale preparation.

Synthesis and hyperglycemic, biochemical and histopathological evaluation of novel sulfonylbiguanide and sulfonylurea derivatives as potent anti-diabetic agents

New sulfonylbiguanide hydrochloride salts and sulfonylurea derivatives containing two sulfonyl groups were synthesized through the reaction of arylsulfonohydrazides with cyanoguanidine and p-tolylsulfonylisocyanate, respectively. Oral treatment of hyperglycemic rats with the synthesized sulfonylbiguanide derivatives 2 and sulfonylurea derivatives 3 revealed that sulfonylurea derivatives 3a and 3c possessed significant decrease of the elevated glucose in compression with the anti-diabetic standard drugs. Effects of the synthesized sulfonylurea derivatives 3a and 3c on the diabetic properties towards α-amylase, liver function enzyme levels (AST, ALT, ALP, TB and γ-GT), kidney functions (urea and creatinine), lipids profiles (TG, TL, TC and HDL-C) were studied. Also, the effect of sulfonylurea derivatives 3a and 3c as antioxidants (reduced glutathione and lipid peroxide) was evaluated. Histopathological examination of hepatic and pancreatic tissues was investigated. The obtained results suggested that the most potent sulfonylurea derivatives 3a and 3c might be possible used as novel diabetic inhibitor agents.

Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO 2·CH 2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates using sulfonyl hydrazides with the assistance of reductant. Additionally, the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.

Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives

An efficient iodine-mediated coupling of cyclic amines with sulfonyl hydrazides is reported. This transformation opens a new route to the synthesis of vinyl sulfones derivatives, which is a common structural motif in natural products and pharmaceuticals. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

NaHSO3-Mediated Direct Synthesis of Sulfinic Esters from Sulfonyl Hydrazides under Transition-Metal-Free Conditions

We have developed a protocol for the NaHSO3-promoted esterification of sulfonyl hydrazides with alcohols for the synthesis of sulfinic esters. Various sulfonyl hydrazides could be converted to the corresponding sulfinic esters in good to high yields. The merits of this protocol include mild transition-metal-free reaction conditions, an inexpensive and available reagent, and operational simplicity. Controlled experiments reveal that this transformation probably undergoes via a radical pathway. (Figure presented.).

Palladium-Catalyzed Asymmetric Hydrosulfonylation of 1,3-Dienes with Sulfonyl Hydrazides

A highly enantio- and regioselective hydrosulfonylation of 1,3-dienes with sulfonyl hydrazides has been realized by using a palladium catalyst containing a monodentate chiral spiro phosphoramidite ligand. The reaction provided an efficient approach to synthetically useful chiral allylic sulfones. Mechanistic studies suggest that the reaction proceeds through the formation of an allyl hydrazine intermediate and subsequent rearrangement to the chiral allylic sulfone product. The transformation of the allyl hydrazine intermediate to the product is the enantioselectivity-determining step.