2751-25-9

Basic information

• Product Name: 4-chlorobenzenesulfonohydrazide
• Synonyms: 4-chlorobenzene-1-sulfonohydrazide; benzenesulfonic acid, 4-chloro-, hydrazide
• CAS NO: 2751-25-9
• Molecular Formula: C₆H₇ClN₂O₂S
• Molecular Weight: 206.65
• Mol File: 2751-25-9.mol
• Article Data: 62

Chemical Properties

• Boiling Point: 359.5°C at 760 mmHg
• Flash Point: 171.2°C
• Density: 1.485g/cm³
• Vapor Pressure: 2.36E-05mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 4-chlorobenzenesulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorobenzenesulfonohydrazide(2751-25-9)
• EPA Substance Registry System: 4-chlorobenzenesulfonohydrazide(2751-25-9)

Safety Data

• Hazardous Substances Data: 2751-25-9(Hazardous Substances Data)

Usage

General Description

4-chlorobenzenesulfonohydrazide, also known as CSH, is a chemical compound used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is a white to off-white crystalline solid that is slightly soluble in water and soluble in organic solvents. CSH is a versatile reagent for the preparation of hydrazone derivatives and is also used in the production of dyes and UV stabilizers. It has a wide range of applications in the chemical industry, including as a precursor in the synthesis of pharmaceuticals, dyes, and agrochemicals. Additionally, it has been used in the development of electrochemical sensors for the detection of organic compounds.

Upstream product

• 98-66-8 4-chloro-benzenesulfonic acid 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 111443-09-5 4-chloro-benzenesulfonic acid-[N'-(tetra-O-acetyl-ξ-D-glucopyranosyl)-hydrazide] 
• 112070-67-4 4-chloro-benzenesulfonic acid-(penta-O-acetyl-D-galactitol-1-ylidenehydrazide) 
• 219711-55-4 2-(4-chloro-benzenesulfonyl)-6-hydroxy-2H-pyridazin-3-one 
• 1200355-97-0 1-(4'-chlorophenylsulfonylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl ester 
• 1136519-32-8 8-(4-chlorophenyl)-1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione 
• 1454773-58-0 (E)-1-((2-bromo-2-phenylvinyl)sulfonyl)-4-chlorobenzene 
• 31599-09-4 (E)-(1-chloro-4-(2-chloro-2-phenylethene)sulfonyl)benzene 
• 2050-68-2 4,4'-dichlorobiphenyl 
• 13343-26-5 phenyl p-chlorophenyl sulfide 
• 36603-45-9 2-((4-chlorophenyl)sulfonyl)-1-phenylethanone 
• 7304-69-0 4-chlorophenyl-S-(N,N-dimethylthiocarbamate) 
• 68253-26-9 4-(4-chlorophenylthio)-N,N-dimethylbenzenamine 
• 832744-28-2 1-(4-bromophenyl)-2-(4-chlorophenyl)ethyne 

Relevant articles and documents

Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers

In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy and LC-MS spectrometry, besides elemental analysis. The compou

Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.

Electrochemical fluorosulfonylation of styrenes

An environmentally friendly and efficient electrochemical fluorosulfonylation of styrenes has been developed. With the use of sulfonylhydrazides and triethylamine trihydrofluoride, a diverse array of β-fluorosulfones could be readily obtained. This reaction features mild conditions and a broad substrate scope, which could also be conveniently extended to a gram-scale preparation.