61820-99-3

Upstream product

• 99-81-0 4-Nitrophenacyl bromide 
• 98-59-9 p-toluenesulfonyl chloride 
• 938-10-3 phenylsulfonyl azide 
• 56858-46-9 1-(4-nitrophenyl)-2-(toluene-4-sulfonyl)ethanone 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 19820-38-3 -methyl-ether 
• 61821-10-1 1-(4-Nitro-phenyl)-2-propoxy-2-(toluene-4-sulfonyl)-ethanone 
• 61821-09-8 2-Ethoxy-1-(4-nitro-phenyl)-2-(toluene-4-sulfonyl)-ethanone 
• 61821-11-2 2-Isopropoxy-1-(4-nitro-phenyl)-2-(toluene-4-sulfonyl)-ethanone 

Relevant academic research and scientific papers

Facile One-Pot Access to α-Diazo-β-ketosulfones from Sulfonyl Chlorides and α-Haloketones

A convenient one-pot approach to the preparation of α-diazo-β-ketosulfones from sulfonyl chlorides is described. It involves the conversion of the sulfonyl chloride to sodium sulfinate, alkylation of the latter with α-haloketones followed by diazo transfer using the 'sulfonyl-azide-free' ('SAFE') protocol in aqueous medium. The simple and expedient method relies on readily available starting materials and provides facile access to a wide variety of valuable diazo reagents for organic synthesis.

Copper Triflate Mediated α-Monohalogenation of α-Diazo β-Ketosulfones with Ammonium Halides

Copper triflate mediated α-monohalogenation of α-diazo β-ketosulfones with ammonium halides provides the corresponding α-halo β-ketosulfones. Different metal triflates are investigated for this facile and efficient transformation. A plausible mechanism is proposed.

Copper Acetate Mediated α-Oxysulfonylation of α-Diazo β-Ketosulfones

Copper acetate mediated α-oxysulfonylation of α-diazo β-ketosulfones in wet nitromethane under nitrogen provides α-oxysulfonyl β-ketosulfones. The use of different copper salts is investigated for the development of a facile and efficient transformation.