61828-53-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-phenylethyl)chromone is used as a pharmaceutical agent for its anti-inflammatory properties, making it suitable for the treatment of conditions such as asthma, allergies, and inflammation. Its ability to modulate immune responses and reduce inflammation contributes to its therapeutic potential in these areas.
Used in Anticancer Applications:
In the field of oncology, 2-(2-phenylethyl)chromone is utilized as an anti-cancer agent. Its inherent properties allow it to target and inhibit the growth of cancer cells, making it a valuable component in the development of cancer treatments.
Used in Antimicrobial Applications:
2-(2-phenylethyl)chromone also serves as an antimicrobial agent, effective against various microorganisms. This makes it a potential candidate for use in the development of antibiotics or other treatments aimed at combating microbial infections.
Used in Drug Development:
Due to its diverse range of biological activities, 2-(2-phenylethyl)chromone is used in the development of new drugs targeting a variety of conditions. Its potential applications span across different areas of medicine, highlighting its versatility and importance in pharmaceutical research.

InChI:InChI=1/C17H14O2/c18-16-12-14(11-10-13-6-2-1-3-7-13)19-17-9-5-4-8-15(16)17/h1-9,12H,10-11H2

Upstream product

• 39103-38-3 (E)-2-styrylchromone 
• 119405-97-9 4-phenyl-1,1-dibromo-1-butene 
• 90-02-8 salicylaldehyde 
• 118-93-4 o-hydroxyacetophenone 
• 645-45-4 hydrocinnamic acid chloride 
• 61828-54-4 1-(2-Hydroxy-phenyl)-5-phenyl-pentane-1,3-dione 

Downstream Products

• 61828-55-5 (S)-2-phenethylchroman-4-one 

Relevant academic research and scientific papers

Rh-Catalyzed aldehydic C-H alkynylation and annulation

Novel Rh-catalyzed aldehydic C-H bond alkynylation and annulation for the in situ synthesis of chromones and aurones are described. It involves the sequential aldehyde C-H bond alkynylation of salicylaldehyde with in situ generated 1-bromoalkyne from 1,1-

An efficient tandem synthesis of chromones from: O -bromoaryl ynones and benzaldehyde oxime

An effective transition-metal-free strategy was developed for the preparation of chromones from o-bromoaryl ynones and benzaldehyde oxime through sequential C-O bond formation. This cyclization reaction could well tolerate a wide range of functional groups, and the corresponding chromones were given in moderate to excellent yields. Mechanistically, benzaldehyde oxime as a hydroxide source and 1,3-diketone derivatives as reaction intermediates were involved in this transformation.

Soft-enolization Baker-Venkataraman Rearrangement Enabled Total Synthesis of Dirchromones and Related 2-Substituted Chromones

A seven-step total synthesis of the original scaffold of cytotoxic dirchromones involving an unprecedented soft-enolization Baker-Venkataraman rearrangement was designed. The methodology enabled access to naturally occurring dirchromone 1 (21% overall yield) at gram-scale, which was screened for cytotoxicity against 13 cancer cell lines. The scope of the soft-enolization Baker-Venkataraman rearrangement encompasses diversely substituted dirchromones, including flavonoids, 2-styrylchromones, and 2-phenylethylchromones.

Synthesis of chiral chromanols: Via a RuPHOX-Ru catalyzed asymmetric hydrogenation of chromones

Chiral chromanols and their derivatives have been synthesized via a RuPHOX-Ru catalyzed asymmetric hydrogenation of chromones in high yields, >20:1 drs and with up to 99.9% ee. Control experiments show that the reaction undergoes two sequential asymmetric hydrogenation steps of the CC and CO double bonds. The reaction could be performed on a gram-scale with a relatively low catalyst loading (up to 1000 S/C), and the resulting products can be transformed to several biologically active compounds.

2-SUBSTITUTED-5-HYDROXY-4H-CHROMEN-4-ONES AS NOVEL LIGANDS FOR THE SEROTONIN RECEPTOR 2B (5-HT2B)

A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT2B) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively strong interaction with 5-HT2B compared to naturally occurring compounds (some of which are identified for the first time herein as ligands for 5-HT2B). Because the compounds, both naturally occurring and synthetically produced, function as ligands for 5-HT2B they will have application in, for example, the treatment and/or prevention of nervous system disorders such as Alzheimer's disease.

Ruthenium-NHC-catalyzed asymmetric hydrogenation of flavones and chromones: General access to enantiomerically enriched flavanones, flavanols, chromanones, and chromanols

Two to four! Readily available flavones and chromones were efficiently converted into four valuable chiral classes of O-heterocycles - flavanones, chromanones, flavanols, and chromanols - by means of an enantioselective Ru/NHC-catalyzed hydrogenation process (see scheme; NHC=N-heterocyclic carbene, PCC=pyridinium chlorochromate). Copyright

An efficient procedure for the preparation of natural products bearing the 2-(2-phenylethyl)chromone skeleton

Several 2-(2-phenylethyl)chromones have been shown to possess neuroprotective activity. However, limited synthetic methods have been disclosed to construct the 2-(2-phenylethyl)chromone skeleton. Herein, we report a straightforward 3-step preparation of f

Synthesis of 2-(2-phenylethyl)chromones

2-(2-Phenylethyl)chromones have been obtained by selective reduction of double bond of the styryl group in 2-styrylchromones involving catalytic hydrogen transfer reaction using ammonium formate in the presence of Pd-C.