61834-24-0Relevant academic research and scientific papers
TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
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Paragraph 002; 004; 0248, (2018/06/12)
Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.
NOVEL AZOLE DERIVATIVES AS APELIN RECEPTOR AGONIST
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Page/Page column 158; 159, (2017/07/05)
The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents -N= or -CH=, X2 represents -CH= or -N=, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.
CONVENIENT SYNTHESIS OF 2,5-DIMETHYL-2-FUROIC ACID
Klein, Larry L.
, p. 431 - 436 (2007/10/02)
A synthesis of 4,5-dimethyl-2-furoic acid amenable to large scale is reported affording the titled compound in 25percent yield.
