618386-06-4Relevant academic research and scientific papers
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity
Chackalamannil, Samuel,Wang, Yuguang,Greenlee, William J.,Hu, Zhiyong,Xia, Yan,Ahn, Ho-Sam,Boykow, George,Hsieh, Yunsheng,Palamanda, Jairam,Agans-Fantuzzi, Jacqueline,Kurowski, Stan,Graziano, Michael,Chintala, Madhu
supporting information; experimental part, p. 3061 - 3064 (2009/04/10)
The discovery of an exceptionally potent series of thrombin receptor (PAR-1) antagonists based on the natural product himbacine is described. Optimization of this series has led to the discovery of 4 (SCH 530348), a potent, oral antiplatelet agent that is
Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents
Chackalamannil, Samuel,Xia, Yan,Greenlee, William J.,Clasby, Martin,Doller, Darìo,Tsai, Hsingan,Asberom, Theodros,Czarniecki, Michael,Ahn, Ho-Sam,Boykow, George,Foster, Carolyn,Agans-Fantuzzi, Jacqueline,Bryant, Matthew,Lau, Janice,Chintala, Madhu
, p. 5884 - 5887 (2007/10/03)
Structurally novel thrombin receptor (protease activated receptor 1, PAR-1) antagonists based on the natural product himbacine are described. The prototypical PAR-1 antagonist 55 showed a Ki of 2.7 nM in the binding assay, making it the most po
