618386-15-5 Usage
Uses
Used in Pharmaceutical Industry:
(3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one is utilized as a therapeutic agent for the treatment of metabolic disorders such as diabetes and obesity. Its ability to inhibit 11β-HSD1 suggests that it can help regulate cortisol levels, which may contribute to the management of these conditions.
Additionally, it is used in the management of inflammatory conditions due to its potential impact on cortisol metabolism, which is implicated in inflammatory processes.
Furthermore, its unique structure and mechanism of action position (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one as a promising candidate for further development in the pharmaceutical sector, with potential applications in a variety of therapeutic areas related to cortisol regulation and associated health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 618386-15-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,8,3,8 and 6 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 618386-15:
(8*6)+(7*1)+(6*8)+(5*3)+(4*8)+(3*6)+(2*1)+(1*5)=175
175 % 10 = 5
So 618386-15-5 is a valid CAS Registry Number.
618386-15-5Relevant academic research and scientific papers
ACTIVE METABOLITE OF A THROMBIN RECEPTOR ANTAGONIST
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Page/Page column 21, (2010/12/29)
Disclosed herein is an active metabolite ( M20 ) of a molecule that is useful as a thrombin receptor antagonist: Also disclosed are formulations of this compound, synthetic routes to this compound, and methods of treating a variety of cardiovascular conditions, including acute coronary syndrome and peripheral arterial disease, and of effecting secondary prevention, by orally administering the active metabolilte.
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity
Chackalamannil, Samuel,Wang, Yuguang,Greenlee, William J.,Hu, Zhiyong,Xia, Yan,Ahn, Ho-Sam,Boykow, George,Hsieh, Yunsheng,Palamanda, Jairam,Agans-Fantuzzi, Jacqueline,Kurowski, Stan,Graziano, Michael,Chintala, Madhu
supporting information; experimental part, p. 3061 - 3064 (2009/04/10)
The discovery of an exceptionally potent series of thrombin receptor (PAR-1) antagonists based on the natural product himbacine is described. Optimization of this series has led to the discovery of 4 (SCH 530348), a potent, oral antiplatelet agent that is
