61844-66-4

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 3095-95-2 diethylphosphonoacetic acid 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 7400-08-0 p-Coumaric Acid 
• 107-30-2 chloromethyl methyl ether 
• 3943-97-3 methyl 4-hydroxycinnamate 
• 847450-00-4 3-(4-methoxymethoxy-phenyl)-acrylic acid ethyl ester 

Downstream Products

• 885703-07-1 3-(4-methoxymethoxy-phenyl)-acrylic acid 3-(4-methoxy-phenyl)-allyl ester 
• 885703-05-9 3-(3,4-dimethoxymethoxyphenyl)propenyl 3-(4-methoxymethoxyphenyl)allylate 
• 850176-71-5 3-(4-methoxymethoxyphenyl)propenyl 3-(4-methoxymethoxyphenyl)allylate 
• 885703-06-0 3-phenylpropenyl 3-(4-methoxymethoxyphenyl)allylate 
• 87099-71-6 3-O-trans-p-coumaroyl-D-quinic acid 

Relevant academic research and scientific papers

Novel tranylcypromine/hydroxylcinnamic acid hybrids as lysine-specific demethylase 1 inhibitors with potent antitumor activity

Novel tranylcypromine/hydroxylcinnamic acid hybrids 15a, b, and 19a-l were designed and synthesized by connecting tranylcypromine with hydroxylcinnamic acid, and their biological activities were evaluated. The in vitro assay of their inhibitory activities

Efficient and versatile synthesis of 5-O-acylquinic acids with a direct esterification using a p-methoxybenzyl quinate as a key intermediate

An efficient and versatile synthesis of 5-O-acylquinic acids from commercially available (-)-quinic acid was accomplished. We designed p-methoxybenzyl quinate as a key intermediate, and two problems, the esterification of the sterically hindered 5-OH group for the concise divergent synthesis and the low yield of the final deprotection step, were solved. For the first problem, we improved Tanabe's method, TsCl/NMI-mediated esterification using free carboxylic acids, by the addition of i-Pr2NEt. For the second problem, we established a TFA- or BCl3/C6HMe5-catalyzed deprotection reaction for the final deprotection step. 5-O-Acylquinic acids were synthesized in seven steps with 45-60% overall yield.

Synthesis and biological evaluation of a natural ester sintenin and its synthetic analogues

Synthesis of 3-(3,4-dimethoxyphenyl)propyl-3-(3,4-dimethoxyphenyl) propanoate (18), a cytotoxic natural ester, was carried out by a convenient synthetic path with a total yield of 49%. Sixteen of its analogues (19-34) were also prepared. Seventeen unsaturated derivatives of 18, compounds 1-17, were also synthesized to examine the structure-activity relationship of this type of ester. All of the synthetic compounds were passed through the cytotoxicity screenings on human tumor cell lines, such as PC-3, Hela, A549, BEL7404, CNE, and KB. Some of the esters exhibited moderate inhibitory effects on these tumor cell lines. The phenolic derivatives exhibited the highest cytotoxicity among these derivatives, while the unsaturated esters were more cytotoxic than the saturated analogues. Some of the compounds also exhibited inhibition on α-glucosidase.

ARYL SULFAMATE DERIVATIVES

The present invention provides an aryl sulfamate derivative represented by Formula (I) (wherein Rr and Rs, which may be the same or different, each represent a hydrogen atom or lower alkyl, R1, R2, R3