618441-58-0 Usage
Uses
Used in Pharmaceutical Research and Development:
(3-phenyl-1-p-tolyl-1H-pyrazol-4-yl)methanol is used as a precursor or intermediate in the synthesis of various biologically active compounds for pharmaceutical applications. Its unique structure allows it to be a key component in the development of new drugs and therapeutics.
Used in Agrochemical Research and Development:
(3-phenyl-1-p-tolyl-1H-pyrazol-4-yl)methanol is also used in the research and development of agrochemicals, where it may serve as a precursor or intermediate in the synthesis of compounds with potential applications in agriculture.
Used in Organic Synthesis:
(3-phenyl-1-p-tolyl-1H-pyrazol-4-yl)methanol is utilized in various organic synthesis applications, where it can be a valuable building block for creating a wide range of chemical compounds with diverse properties and uses.
Check Digit Verification of cas no
The CAS Registry Mumber 618441-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,8,4,4 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 618441-58:
(8*6)+(7*1)+(6*8)+(5*4)+(4*4)+(3*1)+(2*5)+(1*8)=160
160 % 10 = 0
So 618441-58-0 is a valid CAS Registry Number.
618441-58-0Relevant academic research and scientific papers
Synthesis, pharmacological activities and molecular docking studies of pyrazolyltriazoles as anti-bacterial and anti-inflammatory agents
Dayakar, Cherupally,Kumar, Buddana Sudheer,Sneha, Galande,Sagarika, Gudem,Meghana, Koneru,Ramakrishna, Sistla,Prakasham, Reddy Shetty,China Raju, Bhimapaka
, p. 5678 - 5691 (2017/10/09)
A series of novel pyrazolyl alcohols (5a-h), pyrazolyl azides (6a-h), and pyrazolyltriazoles (8a-h, 10a-p and 12a-l) were prepared and evaluated for their bioactivity (anti-bacterial and anti-inflammatory) profile. The compound 5c displayed the potent anti-bacterial activity against Micrococcus luteus (MIC 3.9 and MBC 7.81 μg/mL). In vitro anti-inflammatory activity data denoted that compound 8b is effective among the tested compounds against IL-6 (IC50 6.23 μM). Docking analysis of compounds 5f, 8a-b, 8e-f and 8h displayed high binding energies for the compounds 8a-b and 8h towards TNF-α dimer (2AZ5 protein) and IL-6 (1ALU protein). In vivo anti-inflammatory activity of compounds 8b and 8h with respect to LPS induced mice model indicated that compound 8h showed significant reduction in TNF-α.
