618446-08-5

Basic information

• Product Name: 4-Aminomethylpyrimidine dihydrochloride
• Synonyms: 4-Aminomethylpyrimidine dihydrochloride;4-Aminomethylpyrimidine h...;4 - pyriMidine MethylaMine Hydrochloride;4-Pyrimidinemethanamine dihydrochloride;4-Pyrimidinemethanamine hydrochloride;pyrimidin-4-ylmethanamine dihydrochloride;4-AMINOMETHYLPYRIMIDINE 2HCL
• CAS NO: 618446-08-5
• Molecular Formula: C5H9Cl2N3
• Molecular Weight: 182.05106
• Mol File: 618446-08-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Aminomethylpyrimidine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Aminomethylpyrimidine dihydrochloride(618446-08-5)
• EPA Substance Registry System: 4-Aminomethylpyrimidine dihydrochloride(618446-08-5)

Safety Data

• Hazardous Substances Data: 618446-08-5(Hazardous Substances Data)

Usage

General Description

4-Aminomethylpyrimidine dihydrochloride is a chemical compound with the molecular formula C5H8N4·2HCl. It is commonly used as an intermediate in the synthesis of pharmaceuticals such as trimethoprim, which is an antibiotic used to treat bacterial infections. 4-Aminomethylpyrimidine dihydrochloride is also used as a building block in the production of various drugs, including antiviral and antifungal agents. 4-Aminomethylpyrimidine dihydrochloride has a variety of potential medical applications and is a valuable tool for medicinal chemists in the development of new drugs. It is categorized as a pyrimidine derivative and is typically handled and stored as a white crystalline powder.

InChI:InChI=1S/C5H7N3.2ClH/c6-3-5-1-2-7-4-8-5;;/h1-2,4H,3,6H2;2*1H

Upstream product

• 1073-65-0 Pyrimidin-aldehyd-(4)-oxim 

Relevant articles and documents

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.