618446-08-5

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Aminomethylpyrimidine dihydrochloride is used as a key intermediate for the production of pharmaceuticals such as trimethoprim, an antibiotic effective against bacterial infections. Its role in the synthesis process is vital for creating effective treatments for a range of bacterial diseases.
Used in Antiviral and Antifungal Drug Production:
4-Aminomethylpyrimidine dihydrochloride is utilized as a building block in the creation of antiviral and antifungal agents, contributing to the development of medications that combat viral and fungal infections, thereby expanding the arsenal of treatments available to address these health challenges.
Used in Medicinal Chemistry Research:
4-Aminomethylpyrimidine dihydrochloride is employed as a valuable tool in medicinal chemistry, aiding researchers in the exploration and development of novel drug candidates. Its versatility and reactivity in chemical reactions make it an indispensable component in the quest for new therapeutic agents.

InChI:InChI=1S/C5H7N3.2ClH/c6-3-5-1-2-7-4-8-5;;/h1-2,4H,3,6H2;2*1H

Upstream product

• 1073-65-0 Pyrimidin-aldehyd-(4)-oxim 

Relevant academic research and scientific papers

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

Substituted alkylamine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.