61852-68-4Relevant academic research and scientific papers
Stereocontrol in a combined allylic azide rearrangement and intramolecular schmidt reaction
Liu, Ruzhang,Gutierrez, Osvaldo,Tantillo, Dean J.,Aube, Jeffrey
supporting information; experimental part, p. 6528 - 6531 (2012/06/15)
Pre-equilibration of an interconverting set of isomeric allylic azides is coupled with an intramolecular Schmidt reaction to afford substituted lactams stereoselectively. The effect of substitution and a preliminary mechanistic study are reported. The syn
Synthesis and Antineoplastic Activity of Bisoxy>methyl>-Substituted 3-Pyrrolines as Prodrugs of Tumor Inhibitory Pyrrole Bis(carbamates)
Anderson, Wayne K.,Milowsky, Arnold S.
, p. 2241 - 2249 (2007/10/02)
A series of bispyrrolines 2-4 were synthesized from either the appropriate α-silylated iminium salt, or an aziridine, or a 2H-azirine in a sequence involving 1,3-dipolar cycloaddition reactions.The antineoplastic activities of the pyrrolines were compared to the corresponding pyrroles.The C-2 gem-dimethyl-substituted pyrroline, 4, which cannot be converted to the pyrrole in vivo, was inactive.The activity of the 2-phenyl-substituted pyrrolines 3 was markedly dependent on the nature of the phenyl substituent, although the correspondingphenylpyrroles all showed comparable activity.The differences in the activities of the pyrrolines 3 may be due to the rate of metabolic conversion of the pyrroline to the pyrrole.Electron-withdrawing substituents on the phenyl ring appear to retard this process.
Determination de la configuration E/Z d'iodures de N,N,N-trimethyl hydrazonium par Resonance Magnetique Nucleaire du proton et du carbone
Arseniyadis, Simeon,Laurent, Andre,Mison, Pierre
, p. 233 - 245 (2007/10/02)
Hydrazones are widely used in stereospecific alkylation reactions and hydrazonium iodides in the synthesis of small rings like azirines or aziridines.An attempt to clear up the mechanism at the latter cyclization led us to carry out a detailled 1/su
