6186-21-6

Basic information

• Product Name: α-acetyl-α-(p-bromophenyl)acetonitrile
• Synonyms: α-acetyl-α-(p-bromophenyl)acetonitrile
• CAS NO: 6186-21-6
• Molecular Weight: 238.084
• Mol File: 6186-21-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: α-acetyl-α-(p-bromophenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: α-acetyl-α-(p-bromophenyl)acetonitrile(6186-21-6)
• EPA Substance Registry System: α-acetyl-α-(p-bromophenyl)acetonitrile(6186-21-6)

Safety Data

• Hazardous Substances Data: 6186-21-6(Hazardous Substances Data)

Upstream product

• 16532-79-9 4-Bromophenylacetonitrile 
• 141-78-6 ethyl acetate 

Downstream Products

• 10557-20-7 1-(4-bromophenyl)-1,2-propanedione 
• 1346260-41-0 (E)-1-(4-bromophenyl)-2-(methoxyimino)propan-1-one 

Relevant articles and documents

N -Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

NF-κB-inducing kinase (NIK), an oncogenic drug target that is associated with various cancers, is a central signalling component of the non-canonical pathway. A blind screening process, which established that amino pyrazole related scaffolds have an effect on IKKbeta, led to a hit-to-lead optimization process that identified the aminopyrazole 3a as a low μM selective NIK inhibitor. Compound 3a effectively inhibited the NIK-dependent activation of the NF-κB pathway in tumour cells, confirming its selective inhibitory profile.