6186-84-1Relevant academic research and scientific papers
Transition-metal-free regioselective thiocyanation of phenols, anilines and heterocycles
Mete, Trimbak B.,Khopade, Tushar M.,Bhat, Ramakrishna G.
supporting information, p. 415 - 418 (2017/01/10)
An expedient direct and regioselective thiocyanation of phenols, anilines and heterocycles is described. Transformation is realized via the direct C[sbnd]H functionalization under transition metal free conditions at ambient temperature in excellent yields. Method proved to be monoselective and variety of functional groups tolerated the reaction conditions. The practicality of the protocol is demonstrated in gram scale synthesis of a precursor of PPAR δ agonist in excellent yield.
