61866-24-8

Upstream product

• 19045-31-9 2,2-dimethyl-3-phenyl-1-butanol 
• 6651-34-9 2-methyl-1-(trimethylsilyloxy)-1-propene 
• 672-65-1 (1-chloroethyl)benzene 
• 29206-01-7 2,2-dimethyl-3-phenyl-butyric acid 
• 4013-34-7 3-phenyl-2-oxabutane 

Relevant academic research and scientific papers

Indium-catalyzed coupling reaction between silyl enolates and alkyl chlorides or alkyl ethers

The coupling reactions of alkyl chlorides with silyl enolates catalyzed by InBr3, and the coupling reactions of alkyl ethers with silyl enolates catalyzed by the combined Lewis acid of InBr3/Me3SiBr are described. In both reaction systems, various types of silyl enolates were used to give corresponding α-alkylated esters, ketones, carboxylic acids, amides, thioesters, and aldehydes.

Coupling reaction of alkyl chlorides with silyl enolates catalyzed by indium trihalide

Indium(III) halide catalyzed not only the coupling of alkyl chlorides with silyl enolates derived from esters, ketones, and aldehydes to give a variety of α-alkylated carbonyl compounds but also one-pot, three-component reactions of aldehyde enolate, alkyl chloride, and allylsilane or alkynylsilane.