61882-64-2Relevant academic research and scientific papers
Highly Reactive and Tracelessly Cleavable Cysteine-Specific Modification of Proteins via 4-Substituted Cyclopentenone
Yu, Jian,Yang, Xiaoyue,Sun, Yang,Yin, Zheng
, p. 11598 - 11602 (2018)
A rapid and cysteine-specific modification of proteins using 4-substituted cyclopentenone via a Michael addition tandem elimination reaction was developed. Compared to the classical method, this reaction featured fast kinetics with a stable product. More importantly, this conjugation could be tracelessly removed by exchange with a Michael addition donor. The conjugation and regeneration process not only exhibited little change to the structures or conformations of the proteins but also exhibited little disturbance to their biological functions, such as their enzymatic activities.
Regio- and diastereo-selectivity in 1,3-dipolar cycloadditions of nitrile oxides to 4-substituted cyclopent-2-enones
Adembri, Giorgio,Giorgi, Gianluca,Lampariello, Raffaella L.,Paoli, Maria L.,Sega, Alessandro
, p. 2649 - 2656 (2007/10/03)
The behaviour of 4-hydroxy-4-methylcyclopent-2-enone and related 4-substituted cyclopent-2-enones towards 1,3-dipolar cycloaddition with nitrile oxides is studied.The reactions are always completely regioselective while the diastereofacial selectivity depends on the nature of the substituents. Remarkably, the reaction of 4-acetoxycyclopent2-enone shows complete regio- and diastereo-facial selectivity. The Royal Society of Chemistry 2000.
