61885-21-0

Upstream product

• 4344-87-0 1,2-dihydro-5-methyl-3H-pyrazol-3-one 
• 67-64-1 acetone 
• 110-46-3 isopentyl nitrite 
• 60-29-7 diethyl ether 
• 6386-15-8 4-Isonitroso-3-methyl-pyrazolon-(5) 
• 13572-24-2 3-methyl-4-(2-phenylhydrazono)-1H-pyrazol-5(4H)-one 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 55326-07-3 1,3,6-trimethyl-5-nitrouracil 

Relevant academic research and scientific papers

Nucleophilic ring-opening of the azole and azine moieties in 6-nitro-1,2,4-triazolo[1,5-a]pyrimidin-7-ones

The effects of the nature of the nucleophile and the structure of 6-nitrotriazolo[1,5-a]pyrimidinones on the direction of the ring opening were investigated. The triazole ring is opened under the action of strong bases, such as alkoxides or alkalis, to form 2-cyanoaminopyrimidinones and then 2-aminopyrimidinones. The results of the reactions with N-nucleophiles depend on the accessibility of position 5 of the heterocycle. Thus, sterically hindered secondary amines react with 5-methyltriazolopyrimidinones to give 2-guanidinopyrimidinones and then 2-aminopyrimidinones. In the absence of a substituent at position 5, the azine ring is opened to form 4-alkyl-3-amino-1,2,4-triazoles and 3-amino-2-nitroacrylamides. Under the action of primary amines, only the pyrimidine fragment is cleaved.

Pyrimidine Derivatives and Related Compounds. Part 41. Reactions of 1,3,6-Trimethyl-5-nitrouracil and its 6-Bromomethyl Analogue with Amines and Hydrazines. Synthesis of Pyrazolopyrimidine N-Oxides and their Ring Expansion to Pyrimidopyrimid

Reactions of 1,3,6-trimethyl-5-nitrouracil (1) and 6-bromomethyl-1,3-dimethyl-5-nitrouracil (4) with amines and hydrazines have been studied with the aim of synthesising fused-ring pyrimidines.Treatment of compound (4) with primary amines afforded 2-subst