618884-71-2

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 68820-81-5 (S)-ethyl 1-((S)-1-phenylethyl)aziridine-2-carboxylate 

Downstream Products

• 1353674-48-2 (S)-2-((R)-10,10-diisopropyl-2,2,3,3,11-pentamethyl-4,9-dioxa-3,10-disiladodecan-5-yl)-1-((S)-1-phenylethyl)aziridine 
• 1353674-49-3 (2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine 
• 1353674-71-1 C₂₉H₄₇NO₄Si 
• 1353674-47-1 C₂₃H₃₉NO₂Si 

Relevant academic research and scientific papers

Nucleophilic trifluoromethylation of aziridinyl ketones: A convenient access to fluorinated aziridinyl alcohols

A convenient synthesis of α-(aziridin-2-yl)-α-(trifluoromethyl) alcohols starting with ethyl aziridine-2-carboxylates is reported. Grignard reaction with the corresponding Weinreb amides led to aziridin-2-yl ketones, and subsequent treatment with Ruppert-Prakash reagent gave the trimethylsilylated target compounds as mixtures of diastereoisomers, which were desilylated with TBAF. In the case of ethyl 1-((S)-1-phenylethyl)aziridine-2-carboxylate, (S,S)- and (S,R)-aziridin-2-yl ketones were obtained, separated chromatographically and transformed into the desired enantiomerically pure α-trifluoromethylated alcohols.

Alkylative ring opening of N -methylaziridinium ions and a formal synthesis of tyroscherin

Alkylative ring-opening reactions of stable 2-substituted N-methylaziridinium ions proceeded with various alkyl- or arylmagnesium bromides in the presence of CuI to yield synthetically valuable and optically pure alkylated acyclic amines in a completely r