618892-00-5Relevant academic research and scientific papers
Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase
Reddy, T. Jagadeeswar,Chan, Laval,Turcotte, Nathalie,Proulx, Melanie,Pereira, Oswy Z.,Das, Sanjoy K.,Siddiqui, Arshad,Wang, Wuyi,Poisson, Carl,Yannopoulos, Constantin G.,Bilimoria, Darius,L'Heureux, Lucille,Alaoui, Hicham M. A.,Nguyen-Ba, Nghe
, p. 3341 - 3344 (2003)
Herein, we describe the structure-activity relationship (SAR) of N,N-disubstituted phenylalanine series of NS5B polymerase inhibitors of hepatitis C. The NS5B polymerase inhibitory activity of the most active compound exhibited an IC50 of 2.7 μ
