618892-24-3

Basic information

• Product Name: 4-(2-benzyloxy-4-fluoro-phenyl)-5-hydroxymethyl-2,6-diisopropyl-nicotinic acid methyl ester
• CAS NO: 618892-24-3
• Molecular Weight: 451.538
• Mol File: 618892-24-3.mol

Chemical Properties

• CAS DataBase Reference: 4-(2-benzyloxy-4-fluoro-phenyl)-5-hydroxymethyl-2,6-diisopropyl-nicotinic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-benzyloxy-4-fluoro-phenyl)-5-hydroxymethyl-2,6-diisopropyl-nicotinic acid methyl ester(618892-24-3)
• EPA Substance Registry System: 4-(2-benzyloxy-4-fluoro-phenyl)-5-hydroxymethyl-2,6-diisopropyl-nicotinic acid methyl ester(618892-24-3)

Safety Data

• Hazardous Substances Data: 618892-24-3(Hazardous Substances Data)

Upstream product

• 470717-49-8 dimethyl 2,6-diisopropyl-4-hydroxy-3,5-pyridine-dicarboxylate 
• 470717-52-3 dimethyl 2,6-diisopropyl-4-methoxy-3,5-pyridine-dicarboxylate 
• 470717-48-7 dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 470717-47-6 dimethyl 2,6-diisopropyl-4-(2'-benzyloxy-4'-fluoro-phenyl)-3,5-pyridinedicarboxylate 

Downstream Products

• 618892-25-4 4-(2-benzyloxy-4-fluoro-phenyl)-5-formyl-2,6-diisopropyl-nicotinic acid methyl ester 
• 503559-86-2 1-[4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-ethanol 
• 503559-82-8 4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridine-3-carbaldehyde 
• 503559-76-0 4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-propenyl)-nicotinic acid methyl ester 
• 503559-84-0 1-[4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-propenyl)-pyridin-3-yl]-ethanol 
• 503559-81-7 4-(2-Benzyloxy-4-fluoro-phenyl)-5-((E)-but-1-enyl)-2,6-diisopropyl-pyridine-3-carbaldehyde 
• 503559-74-8 4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-nicotinic acid methyl ester 
• 503610-15-9 2,6-Diisopropyl-3-(1-hydroxyethyl)-4-(2-hydroxy-4-fluorophenyl)-5-pentylpyridine 
• 503559-80-6 4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-propenyl)-pyridine-3-carbaldehyde 
• 503559-83-9 1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol 
• 202858-58-0 [4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-methanol 
• 202858-60-4 4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridine-3-carbaldehyde 
• 202917-17-7 2,6-Diisopropyl-3-(1-hydroxyethyl)-4-(4-fluoro-2-hydroxyphenyl)-5-propylpyridine 
• 202917-22-4 2-[3-ethyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyridin-4-yl]-5-fluoro-phenol 

Relevant articles and documents

Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists

Optimized substituent patterns in 4-aryl-pyridine glucagon receptor antagonists were merged to produce highly potent derivatives containing both a 3-[(1R)-hydroxyethyl] and a 2′-hydroxy group. Due to restricted rotation of the phenyl-pyridine bond, these analogues exist as four isomers. A diastereoselective methylcopper reaction was developed to facilitate the synthesis, and single isomers were isolated with activities in the range IC50=10-25 nM.