503559-83-9

Basic information

• Product Name: 1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol
• Synonyms: 1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol
• CAS NO: 503559-83-9
• Molecular Weight: 433.566
• Mol File: 503559-83-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol(503559-83-9)
• EPA Substance Registry System: 1-[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-ethanol(503559-83-9)

Safety Data

• Hazardous Substances Data: 503559-83-9(Hazardous Substances Data)

Upstream product

• 618892-24-3 4-(2-benzyloxy-4-fluoro-phenyl)-5-hydroxymethyl-2,6-diisopropyl-nicotinic acid methyl ester 
• 503559-74-8 4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-nicotinic acid methyl ester 
• 618892-25-4 4-(2-benzyloxy-4-fluoro-phenyl)-5-formyl-2,6-diisopropyl-nicotinic acid methyl ester 
• 202858-58-0 [4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-methanol 
• 470717-47-6 dimethyl 2,6-diisopropyl-4-(2'-benzyloxy-4'-fluoro-phenyl)-3,5-pyridinedicarboxylate 
• 470717-49-8 dimethyl 2,6-diisopropyl-4-hydroxy-3,5-pyridine-dicarboxylate 
• 470717-52-3 dimethyl 2,6-diisopropyl-4-methoxy-3,5-pyridine-dicarboxylate 
• 470717-48-7 dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 1184-53-8 methylcopper 
• 202858-60-4 4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridine-3-carbaldehyde 

Downstream Products

• 202917-22-4 2-[3-ethyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyridin-4-yl]-5-fluoro-phenol 

Relevant articles and documents

Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists

Optimized substituent patterns in 4-aryl-pyridine glucagon receptor antagonists were merged to produce highly potent derivatives containing both a 3-[(1R)-hydroxyethyl] and a 2′-hydroxy group. Due to restricted rotation of the phenyl-pyridine bond, these analogues exist as four isomers. A diastereoselective methylcopper reaction was developed to facilitate the synthesis, and single isomers were isolated with activities in the range IC50=10-25 nM.