61892-07-7Relevant articles and documents
SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING A 3'-TERMINAL PHOSPHATE GROUP
Veiko, V. P.,Oretskaya, T. S.,Volkov, E. M.,Metelev, V. G.,Romanova, E. A.,Potapov, V. K.
, p. 601 - 605 (2007/10/02)
Two methods for synthesizing oligodeoxyribonucleotides containing 3'-terminal phosphate groups have been developed.The first consists in the synthesis and the introduction into the oligonucleotides of a block containing a 3'-terminal bis(2-cyanoethyl) phosphate group and the second in the use of the transesterification reaction of oligonucleotides with 2-cyanoethanol in the presence of cesium fluoride.Both methods permit the fairly effective synthesis of oligodeoxyribonucleotide 3'-phosphates.