61903-11-5Relevant academic research and scientific papers
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers
Martini, Elisabetta,Salvicchi, Alberto,Ghelardini, Carla,Manetti, Dina,Dei, Silvia,Guandalini, Luca,Martelli, Cecilia,Melchiorre, Michele,Cellai, Cristina,Scapecchi, Serena,Teodori, Elisabetta,Romanelli, Maria Novella
experimental part, p. 7606 - 7614 (2011/02/24)
A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been syn-thesized and tested for cognition-enhancing acti
Mono-acylation of piperazine and homopiperazine via ionic immobilization
Pringle, Wallace
, p. 5047 - 5049 (2008/12/21)
A method for the selective mono-acylation of piperazine and homopiperazine has been developed. In a flow system, initially the diamine is ionically immobilized on a sulfonic acid funtionalized silica gel, acylated with an appropriate reagent and finally liberated with ammonic methanol. Examples with high yield and purity are presented.
