61923-84-0

Basic information

• Product Name: 2H-Pyrrol-2-one, 1,5-dihydro-4-phenyl-1-(phenylmethyl)-
• CAS NO: 61923-84-0
• Molecular Formula: C17H15NO
• Molecular Weight: 249.312
• Mol File: 61923-84-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2H-Pyrrol-2-one, 1,5-dihydro-4-phenyl-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyrrol-2-one, 1,5-dihydro-4-phenyl-1-(phenylmethyl)-(61923-84-0)
• EPA Substance Registry System: 2H-Pyrrol-2-one, 1,5-dihydro-4-phenyl-1-(phenylmethyl)-(61923-84-0)

Safety Data

• Hazardous Substances Data: 61923-84-0(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 64330-46-7 1-benzyl-1,5-dihydro-2H-pyrrole-2-one 
• 98-80-6 phenylboronic acid 
• 945-93-7 ethyl (E)-3-phenylbut-2-enoate 
• 143704-79-4 (Z)-ethyl 4-bromo-3-phenylbut-2-enoate 
• 127229-66-7 Ethyl 2-chloro-3-phenyl-3-butenoate 

Downstream Products

• 53646-88-1 1-benzyl-3-phenyl-1H-pyrrole 
• 108303-98-6 N-benzyl-4-phenylpyrrolidin-2-one 
• 1026-59-1 (rac)-N-benzyl-3-phenylpyrrolidine 

Relevant articles and documents

Iron-Catalyzed Carbenoid-Transfer Reactions of Vinyl Sulfoxonium Ylides: An Experimental and Computational Study

A method for the generation of unprecedented vinyl carbenoids from sulfoxonium ylides has been developed and applied in the synthesis of a diverse array of heterocycles such as indolizines, pyrroles, 3-pyrrolin-2-ones, and furans. The reactions proceed by FeBr2 catalysis under mild reaction conditions with a broad substrate scope. A reaction pathway involving iron carbenoids is proposed based on a series of control experiments and DFT calculations.

New ring expansion of cyclobutanones: Synthesis of pyrrolinones, pyrrolidines and pyrroles

2,2-Dichlorocyclobutanones reacted with various amines to give ring opening leading to 4,4-dichlorobutanamides. These compounds proved to be suitable substrates for the synthesis of 3-pyrrolin-2-ones, 2-pyrrolidinones, pyrrolidines and pyrroles.

Synthesis and Reactions of α-Chloro-β,γ-unsaturated Esters. 1

Four new α-chloro-β,γ-unsaturated esters were prepared in good yield by the reaction of hypochlorous acid with substituted ethyl 2-butenoates.Reaction of these substituted allylic chlorides with several nucleophiles has been investigated.Thiophenol in the presence of aqueous sodium hydroxide react with ethyl 2-chloro-3-methyl-3-butenoate (2) to give 6, whereas ethyl 2-chloro-2,3-dimethyl-3-butenoate (1) is unreactive.Tertiary allylic chlorides 1, 3 and 4 react with secondary amines to give exclusive abnormal SN2 reaction products.With benzylamine abnormal SN2 substitution is followed by cyclization to give 1-benzyl-3-pyrrolin-2-ones.While ethyl lithioacetate reacts with 1 to give acylation product 18, sodium diphenylmethide in liquid ammonia undergoes alkylation on the tertiary carbon possibly by an electron-transfer reaction pathway.Lithio-1,3-dithiane reacts with 1 to give 2,3-dimethyl-6,10-dithiaspirodec-2-en-1-one (20) via a two-step process, viz., acylation followed by anovel variation of the intramolecular abnormal SN2 reaction.Raney nickel desulfurization of 20 gave 2,3-dimethyl-2-cyclopenten-1-one.Synthetic and mechanistic implications of these results are discussed.