619306-99-9

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 2-(phenylmethyl)-, 1-(1,1-dimethylethyl) 2-ethyl ester, (2S)-
• Synonyms: 1,2-Pyrrolidinedicarboxylic acid,2-(phenylmethyl)-,1-(1,1-dimethylethyl)2-ethyl ester,(2S)
• CAS NO: 619306-99-9
• Molecular Formula: C19H27NO4
• Molecular Weight: 332.41400
• Mol File: 619306-99-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 2-(phenylmethyl)-, 1-(1,1-dimethylethyl) 2-ethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 2-(phenylmethyl)-, 1-(1,1-dimethylethyl) 2-ethyl ester, (2S)-(619306-99-9)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 2-(phenylmethyl)-, 1-(1,1-dimethylethyl) 2-ethyl ester, (2S)-(619306-99-9)

Safety Data

• Hazardous Substances Data: 619306-99-9(Hazardous Substances Data)

Upstream product

• 3081-24-1 H-Phe-OEt 
• 1345336-02-8 C₂₁H₂₇NO₃ 
• 3182-93-2 (L)-phenylalanine ethyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 619306-98-8 (S)-N-(3-bromopropyl)-N-(tert-butoxycarbonyl)phenylalanine ethyl ester 
• 391642-61-8 N-(3-hydroxypropyl)-L-phenylalanine ethyl ester 

Downstream Products

• 1384423-56-6 (R)-1,3-dibenzyl-3-fluoropiperidine 
• 1384423-52-2 (S)-(1,2-dibenzylpyrrolidin-2-yl)methanol 
• 637020-57-6 (S)-α-benzyl proline 
• 918437-82-8 2-[2-(toluene-4-sulfonyloxy)-ethyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 

Relevant articles and documents

Ring expansion of cyclic β-amino alcohols induced by diethylaminosulfur trifluoride: Synthesis of cyclic amines with a tertiary fluorine at C3

As the replacement of a hydrogen atom by a fluorine atom in a compound can have an important impact on its biological properties, the development of methods allowing the introduction of a fluorine atom is of great importance. The scope and limitations of

Asymmetric Cyclization via Memory of Chirality: A Concise Access to Cyclic Amino Acids with a Quaternary Stereocenter

N-(ω-Bromoalkyl)-amino acid derivatives, readily prepared from natural α-amino acids, gave cyclic amino acids with a quaternary stereocenter by treatment with potassium hexamethyldisilazaide in DMF. The chirality of parent amino acids was almost completely preserved during an enolate-formation and cyclization process, giving aza-cyclic amino acids in up to 98% ee in retention of configuration. This method is applicable to the asymmetric synthesis of azetidine, pyrrolidine, piperidine, and azepane derivatives. The asymmetric cyclization seems to proceed via an axially chiral enolate intermediate and not through a concerted SEi process. Copyright