619307-08-3

Upstream product

• 3081-24-1 H-Phe-OEt 

Downstream Products

• 619307-09-4 (R)-ethyl N-(tert-butoxycarbonyl)-2-benzylazetidine-2-carboxylate 
• 1384423-55-5 (S)-1,3-dibenzyl-3-fluoropyrrolidine 
• 1384423-51-1 (R)-(1,2-dibenzylazetidin-2-yl)methanol 
• 681456-98-4 (R)-methyl 1-(4-methoxybenzyl)-2-benzylazetidine-2-carboxylate 
• 918437-86-2 2-[2-(toluene-4-sulfonyloxy)-ethyl]-azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 918437-83-9 2-benzyl-azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Relevant academic research and scientific papers

Ring expansion of cyclic β-amino alcohols induced by diethylaminosulfur trifluoride: Synthesis of cyclic amines with a tertiary fluorine at C3

As the replacement of a hydrogen atom by a fluorine atom in a compound can have an important impact on its biological properties, the development of methods allowing the introduction of a fluorine atom is of great importance. The scope and limitations of

OPTICALLY ACTIVE CYCLIC AMINO ACID DERIVATIVE, ITS INTERMEDIATE AND THEIR MANUFACTURING METHODS

PROBLEM TO BE SOLVED: To provide a new cyclic amino acid derivative useful as a synthetic intermediate for drugs and agricultural chemicals, its intermediate, and a method of manufacturing the compound having high general-purpose properties which can be applied to 4- to 6-membered rings and can obtain a target product with an extremely high optical selectivity. SOLUTION: The optically active amino acid derivative represented by formula (1) is obtained by derivatizing an optically active amino acid represented by formula (3) as a raw material to an N-haloalkylamino acid derivative represented by formula (2) and reacting the compound with a base.