61935-49-7

Upstream product

• 501-53-1 benzyl chloroformate 
• 128052-92-6 (±)-cis-2-aminocyclopentane-1-carboxylic acid hydrochloride 
• 57043-00-2 (1RS,2SR)-cispentacin 
• 57043-01-3 (+/-)-trans-2-amino-cyclopentane carboxylic acid 

Downstream Products

• 114745-58-3 {2-[((1S,2R)-2-Benzyloxycarbonylamino-cyclopentanecarbonyl)-amino]-acetylamino}-acetic acid ethyl ester 
• 135053-11-1 trans-2-aminocyclopentanecarboxamide 
• 135053-11-1 cis-2-amino-1-cyclopentanecarboxamide 
• 114745-58-3 {2-[((1S,2S)-2-Benzyloxycarbonylamino-cyclopentanecarbonyl)-amino]-acetylamino}-acetic acid ethyl ester 
• 206760-20-5 [2-((R)-1-Phenyl-ethylcarbamoyl)-cyclopentyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

A novel, microwave-assisted method for the synthesis of alicyclic-condensed 5H-1,4,6,7-tetrahydro-1,4-diazepin-5-ones

An efficient, high-yielding method has been developed for the synthesis of cycloalkane-fused and phenyl-substituted 1,4-diazepin-5-ones from β-amino acids. The process involves the oxidative cleavage of a terminal olefin bond and an acid-catalyzed, microw

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P2 amino acid by 2-aminoaryl acids and other non-natural amino acids

As a continuation of our SAR studies of dipeptidyl aspartyl-fmk as caspase inhibitors, we explored the replacement of the P2 amino acid by a 2-aminoaryl acid or other non-natural amino acids. Several of these compounds, such as 6l and 6p, were

A novel preparation of 2-aminocyclopentanecarboxamides

Different syntheses of cis- and trans-2-aminocyclopentanecarboxamides were studied. A convenient and effective method was devised for the preparation of cis-2-aminocyclopentanecarboxamide derivatives starting from the readily available 6-tert-butoxycarbon

Preparation of cycloalkane-fused dihydropyrimidin-4(3H)-one enantiomers

Racemic cis-2-amino-1-cyclopentane- or -cyclohexane-1-carboxylic acid was reacted with (R)-α-methylbenzylamine to form homochiral amides 3, 4 and 8, 9. The ring closures of 3, 4 and 8, 9 with aryl imidates resulted in cyclopentane cis-fused and cyclohexane cis- and trans-fused dihydropyrimidin- 4-one enantiomers with loss of the N-substituent. The absolute configurations were determined by hydrolysis of 5, 6 and 10-13 to the corresponding amino acids.