61941-87-5

Usage

Uses

Used in Pharmaceutical Industry:
5-(3-NITROPHENYL)FURAN-2-CARBONYL CHLORIDE is used as a reagent in the synthesis of various pharmaceuticals. Its acylating properties make it a valuable component in the creation of new drug molecules.
Used in Agrochemical Industry:
In the agrochemical industry, 5-(3-NITROPHENYL)FURAN-2-CARBONYL CHLORIDE is utilized for the synthesis of different agrochemicals. Its role as a reagent aids in the development of substances that can protect crops and enhance agricultural productivity.
Safety Precautions:
Due to its reactivity and potential for causing skin and eye irritation, 5-(3-NITROPHENYL)FURAN-2-CARBONYL CHLORIDE should be handled and used with caution. Proper safety measures, including the use of personal protective equipment, should be taken to minimize risks associated with its use.

InChI:InChI=1/C11H6ClNO4/c12-11(14)10-5-4-9(17-10)7-2-1-3-8(6-7)13(15)16/h1-6H

Upstream product

• 41019-37-8 5-(3-nitrophenyl)-furan-2-carboxylic acid methyl ester 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 13331-27-6 m-nitrobenzene boronic acid 
• 99-09-2 3-nitro-aniline 
• 88-14-2 2-furanoic acid 
• 13130-13-7 5-(3-nitro-phenyl)-furan-2-carboxylic acid 

Downstream Products

• 1620099-68-4 2-[5-(3-nitrophen-1-yl)-furan-2-yl-carbonyl]-1,2,3,4 tetrahydro-β-carboline 
• 753499-70-6 (1,4-diaza-bicyclo[3.2.2]non-4-yl)-5-(3-nitrophenyl)-furan-2-yl-methanone 
• 1354698-13-7 N-5-(3'-nitrophenyl)-2-furoyl-1H-pyrazole 
• 140160-23-2 5-(3-Nitro-phenyl)-furan-2-carbonyl isothiocyanate 
• 1007552-01-3 C₁₆H₉ClN₂O₅ 
• 41019-37-8 5-(3-nitrophenyl)-furan-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal toxicity. In this study, fifteen 5-phenyl-2-furan derivatives containing 1,3

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

Novel S-Thiazol-2-yl-furan-2-carbothioate Derivatives as Potential T3SS Inhibitors against Xanthomonas oryzae on Rice

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv oryzae (Xoo) is considered as the most destructive disease of rice. The use of bactericides is among the most widely used traditional methods to control this destructive disease. The excessive an

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell

Multidrug resistance (MDR) is a tendency in which cells become resistant to structurally and mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the noteworthy problems in cancer therapy. As one of the most important

Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors

A series of 3,5-dimethylpyrazole derivatives containing 5-phenyl-2-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. Bioassay results showed that the title compounds exhibited considerable inhibitory activity agains

Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors

Tetrahydroquinoline and tetrahydroisoquinoline derivatives containing 2-phenyl-5-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds showed good inhibitory activity aga

Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors

A series of pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds exhibited considerable inhibitory activit

Synthesis and bioactivity of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan

A series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were synthesized. The antitumor tests showed that the title compounds exhibited promising activity against Bel-7402 and KB. The fungicidal tests showed that most of the title c

Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines

A series of N-substituted tetrahydro-β-carbolines were synthesized and screened for antileishmanial activity through an in vitro assay that involves promastigotes and axenic amastigotes of Leishmania donovani, the causative agent for visceral leishmaniasis. The thiophen-2-yl analogs 9b and 11f and naphthyl analog 11h were found to show significant activity against promastigotes with IC50 values of 12.7, 9.1 and 22.1 μM, respectively. Analogs 9b and 11h were also effective against axenic amastigotes with IC50 values of 62.8 and 87.6 μM, respectively. The antileishmanial activity of analogs was then tested in human macrophage cell line infected with L. donovani amastigotes and 2-naphthyl linked analog 11h was found to be effective with IC50 value of 28.3 μM. Several analogs also displayed antitrypanosomal activity against Trypanosoma brucei, the causative agent for human African trypanosomiasis. Compounds 11e, 11f and 11h were more effective than others with IC50 values of 1.0, 8.9 and 10.2 μM, respectively. All synthesized analogs were not cytotoxic towards mammalian cell lines including Vero (monkey kidney fibroblasts), HEPG2 (human hepatoma cells), LLC-PK1 (pig kidney epithelial cells) and THP-1 (human macrophages).