61948-65-0 Usage
Description
4-Quinazolinamine, 2-chloro-8-methoxy-, is a chemical compound with the molecular formula C9H8ClN3O. It is a quinazoline derivative featuring a chlorine atom at the 2-position and a methoxy group at the 8-position. 4-Quinazolinamine, 2-chloro-8-methoxyhas garnered attention for its potential pharmaceutical properties, particularly as an anti-cancer agent, and has also been considered as a building block in organic synthesis.
Uses
Used in Pharmaceutical Applications:
4-Quinazolinamine, 2-chloro-8-methoxyis used as an anti-cancer agent for its ability to inhibit the growth of cancer cells both in vitro and in animal models. Its potential as a pharmaceutical candidate is attributed to its demonstrated efficacy in combating cancer, making it a promising subject for further drug development.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Quinazolinamine, 2-chloro-8-methoxyis utilized as a building block. Its unique structure and functional groups make it a valuable component in the creation of more complex organic compounds, contributing to the advancement of synthetic chemistry.
Used in Research and Development:
4-Quinazolinamine, 2-chloro-8-methoxyis also used in research and development settings to explore its full potential in medicinal chemistry and synthetic applications. Ongoing studies aim to understand its mechanisms of action and to optimize its properties for various uses, furthering its relevance in the scientific community.
Check Digit Verification of cas no
The CAS Registry Mumber 61948-65-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,9,4 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 61948-65:
(7*6)+(6*1)+(5*9)+(4*4)+(3*8)+(2*6)+(1*5)=150
150 % 10 = 0
So 61948-65-0 is a valid CAS Registry Number.
61948-65-0Relevant articles and documents
IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
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, (2019/07/19)
Disclosed are compounds having the structure of Formula I, or a pharmaceutically acceptable salt of any thereof: wherein: "Z" and R1 are defined herein, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.
Process for preparing quinazolines
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, (2008/06/13)
2-Halo-4-aminoquinazolines are produced by a two-step process involving cyclization of 1-phenyl-3-cyanoureas or 1-phenyl-3-cyanothioureas in the presence of phosphorus halides and phosphorus oxyhalides to provide a phosphoquinazoline intermediate which is hydrolyzed to the quinazoline. Exemplary of the process is the intramolecular cyclization of 1-(3,4-dimethoxyphenyl)-3-cyanourea in the presence of phosphorus pentachloride and phosphorus oxychloride to a phosphoquinazoline intermediate which is subsequently hydrolyzed with formic acid to 2-chloro-4-amino-6,7-dimethoxy-quinazoline. The 2-halo-4-aminoquinazolines of the instant process are particularly valuable as intermediates in the preparation of 4-amino-2-(4-substituted-piperazin-l-yl)quinazolines useful in the treatment of cardiovascular disease, e.g. hypertension.
