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61948-86-5

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61948-86-5 Usage

General Description

5-methoxy-2,4(1H,3H)-quinazolinedione is a chemical compound with the molecular formula C9H8N2O3. It is a quinazoline derivative that has a methoxy group attached to the 5-position of the quinazoline ring. 2,4(1H,3H)-Quinazolinedione, 5-methoxy- has been studied for its potential use in the treatment of various diseases and conditions, including cancer and neurodegenerative disorders. It has also been investigated for its potential as a building block in the synthesis of other organic compounds. 5-methoxy-2,4(1H,3H)-quinazolinedione is a versatile and valuable chemical that has shown promise in various fields of research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 61948-86-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,9,4 and 8 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 61948-86:
(7*6)+(6*1)+(5*9)+(4*4)+(3*8)+(2*8)+(1*6)=155
155 % 10 = 5
So 61948-86-5 is a valid CAS Registry Number.

61948-86-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methoxy-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

1.2 Other means of identification

Product number -
Other names 5-methoxy-1,2,3,4-tetrahydroquinazoline-2,4-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:61948-86-5 SDS

61948-86-5Relevant articles and documents

Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments

Lee, Jun Young,Shin, Young Sup,Jeon, Sangeun,Lee, Se In,Noh, Soojin,Cho, Jung-Eun,Jang, Min Seong,Kim, Seungtaek,Song, Jong Hwan,Kim, Hyoung Rae,Park, Chul Min

supporting information, (2021/03/15)

Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7-chloro-2-((3,5-dichlorophenyl)amino)quinazolin-4(3H)-one (9g) and 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one (11e) showed the most potent anti-SARS-CoV-2 activities (IC50 50 50 > 25 μM). In addition, both compounds showed acceptable results in metabolic stabilities, hERG binding affinities, CYP inhibitions, and preliminary PK studies.

FRET enabled real time detection of RNA-small molecule binding

Xie, Yun,Dix, Andrew V.,Tor, Yitzhak

experimental part, p. 17605 - 17614 (2010/04/01)

A robust analysis and discovery platform for antibiotics targeting the bacterial rRNA A-site has been developed by incorporating a new emissive U surrogate into the RNA and labeling the aminoglycosides with an appropriate fluorescence acceptor. Specifical

Tricyclic dicarbonyl derivatives

-

, (2008/06/13)

Compounds of general formula (Ia), (Ib) and (II), wherein R1 and R2 each independently signify hydrogen, lower alkyl, lower alkoxy, nitro, trifluoromethyl, amino, halogen, cyano or R3 R4 NS(O)2 -- and R3 and R4 signify lower alkyl, and R2 can additionally signify morpholino or thiomorpholino, a 5- or 6-membered heterocycle with 1-3N atoms optionally substituted by lower alkyl, hydroxy, amino or the group --CH2 NHCH3, a bicyclic heterocycle with 1-3N atoms or a group --NR5 R6 or --OR5 in which R5 and R6 can be the same or different and signify hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, amino-lower alkyl or lower alkylamino-lower alkyl, and X in formula (II) signifies --CH=CH--, --CH=N--, --NH--, --CO-- or --O--, as well as pharmaceutically usable salts of compounds of general formula (Ia), (Ib) and (II). They can be used for the treatment or prevention of illnesses, especially for the treatment or prevention of ischemia, hypoglycaemia, hypoxia, cerebral vascular spasms, spasticity, trauma, hemorrhagia, infection (viral, bacterial, amoebic, prional), epileptic seizures, autoimmune diseases, withdrawal symptoms, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, intoxications, olivoponto-cerebellar atrophy, spinal cord injuries, schizophrenia, depressions, anxiety states, dependence, pains,autism and mental retardation.

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