61950-53-6

Basic information

• Product Name: 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one
• Synonyms: 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one
• CAS NO: 61950-53-6
• Molecular Weight: 236.354
• Mol File: 61950-53-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one(61950-53-6)
• EPA Substance Registry System: 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one(61950-53-6)

Safety Data

• Hazardous Substances Data: 61950-53-6(Hazardous Substances Data)

Upstream product

• 878-47-7 (4aS,5S)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one 
• 115-11-7 isobutene 
• 50302-16-4 (4aS,5S)-5-Hydroxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one 

Downstream Products

• 69268-96-8 (3R,4aS,5S)-1,3-Bis-benzenesulfonylmethyl-5-tert-butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one 
• 61930-70-9 1β-tert.-butoxy-8aβ-methyl-5-(phenylsulfonylmethyl)-1,2,3,4,6,7,8,8a-octahydronaphthalene-6-one 
• 65083-12-7 17aβ-(t-Butoxy)-3-methoxy-D-homo-9,10-secooestra-1,3,5(10),8(14)-tetraen-6,9-dion 
• 61921-44-6 (1S,4aS,5S,8aS)-1-Benzenesulfonylmethyl-5-tert-butoxy-4a-methyl-octahydro-naphthalen-2-one 
• 61921-44-6 (1R,4aS,5S,8aR)-1-Benzenesulfonylmethyl-5-tert-butoxy-4a-methyl-octahydro-naphthalen-2-one 
• 65083-05-8 17aβ-(t-Butoxy)-3-methoxy-D-homo-9,10-secooestra-1,3,5(10)-trien-9-on 
• 65137-51-1 (1R,4aS,5S,8aR)-5-tert-Butoxy-1-[2-(3-methoxy-phenyl)-ethyl]-4a-methyl-octahydro-naphthalen-2-one 
• 65137-50-0 (1S,4aS,5S,8aR)-5-tert-Butoxy-1-[2-(3-methoxy-phenyl)-ethyl]-4a-methyl-octahydro-naphthalen-2-one 
• 65083-06-9 17aβ-(t-Butoxy)-3-methoxy-D-homo-9,10-secooestra-1,3,5(10)-trien-6,9-dion 
• 1232-88-8 D-Homo-8-isooestron-methylether 
• 1232-89-9 3-Methoxy-D-homo-oestra-1,3,5(10)-trien-17a-on 

Relevant articles and documents

Improved Preparation of Enantiomerically Pure (+)-(4aS,5S)-5-tert-Butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone

(+)-(4aS,5S)-5-tert-Butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone (6) is a key intermediate in the synthesis of D-homosteroids.Compound 6 was prepared in a five-step sequence via the Wieland-Miescher ketone 4, following the Eder-Sauer-Wiechert-Hajos procedure involving asymmetric intramolecular aldol condensation of the prochiral trione 2 using catalytic amounts of L-proline, with an ee of 63-70percent.Enantiomerically pure 6 was obtained by recrystallization from petroleum ether.

Two-carbon intercalation. 4-cyclooctenones by tandem application of double tebbe and claisen reactions

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