1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one

Base Information

• Chemical Name: 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one
• CAS No.: 61950-53-6
• Molecular Formula: C₁₅H₂₄O₂
• Molecular Weight: 236.354
• Mol file: 61950-53-6.mol

Synonyms:1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one

Chemical Property of 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one

There total 2 articles about 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(4aS,5S)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one (878-47-7,4242-00-6,34996-06-0,50302-16-4,70191-02-5,34996-05-9) + isobutene (115-11-7,15220-85-6) → 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one (61950-53-6,53662-94-5)

Guidance literature:

In dichloromethane; for 16h; Ambient temperature;

Reference yield: 3.0%

(4aS,5S)-5-Hydroxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one (50302-16-4) + isobutene (115-11-7,15220-85-6) → 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one (61950-53-6,53662-94-5) + (4aS,5R)-5-tert-Butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

Guidance literature:

With phosphoric acid; boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 4h;

Reference yield:

N,N,N',N'-tetramethylethylendiamine (815-62-3) + 1β-tert-butoxy-8aβ-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-6-one (61950-53-6,53662-94-5) + Benzenesulfinic acid (618-41-7) → 1β-tert.-butoxy-8aβ-methyl-5-(phenylsulfonylmethyl)-1,2,3,4,6,7,8,8a-octahydronaphthalene-6-one (61930-70-9)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; paraformaldehyde; In chloroform; acetic acid;

upstream raw materials:

(4aS,5S)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one

isobutene

(4aS,5S)-5-Hydroxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

Downstream raw materials:

(3R,4aS,5S)-1,3-Bis-benzenesulfonylmethyl-5-tert-butoxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

1β-tert.-butoxy-8aβ-methyl-5-(phenylsulfonylmethyl)-1,2,3,4,6,7,8,8a-octahydronaphthalene-6-one

17aβ-(t-Butoxy)-3-methoxy-D-homo-9,10-secooestra-1,3,5(10),8(14)-tetraen-6,9-dion

3-Methoxy-D-homo-oestra-1,3,5(10)-trien-17a-on