61956-65-8

Basic information

• Product Name: 3-ETHOXYBENZOYL CHLORIDE
• Synonyms: M-ETHOXYBENZOYL CHLORIDE;3-ETHOXYBENZOYL CHLORIDE;Benzoyl chloride, 3-ethoxy- (9CI);benzoyl chloride, 3-ethoxy-
• CAS NO: 61956-65-8
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• Product Categories: ACIDHALIDE;Aromatic Halides (substituted)
• Mol File: 61956-65-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 261 °C at 760 mmHg
• Flash Point: 97.2 °C
• Appearance: /
• Density: 1.18 g/cm³
• CAS DataBase Reference: 3-ETHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ETHOXYBENZOYL CHLORIDE(61956-65-8)
• EPA Substance Registry System: 3-ETHOXYBENZOYL CHLORIDE(61956-65-8)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 61956-65-8(Hazardous Substances Data)

Usage

General Description

3-Ethoxybenzoyl chloride is a chemical compound that belongs to the class of benzoyl chlorides. It consists of a benzene ring with an attached ethoxy group and a carbonyl chloride functional group. 3-ETHOXYBENZOYL CHLORIDE is typically used as a reagent for the synthesis of various organic compounds, such as pharmaceuticals, agrochemicals, and dyes. It can undergo reactions with different nucleophiles, such as amines and alcohols, to form new carbon-carbon or carbon-oxygen bonds. Additionally, 3-ethoxybenzoyl chloride is known for its strong acylating properties, making it widely utilized in organic synthesis for the modification of aromatic substrates. However, it should be handled with caution due to its corrosive and toxic nature.

Upstream product

• 621-51-2 3-ethoxybenzoic acid 
• 79-37-8 oxalyl dichloride 
• 99-06-9 3-Carboxyphenol 

Downstream Products

• 2346-17-0 3-ethoxy-benzoic acid-(2-diethylamino-ethyl ester); hydrochloride 
• 1312763-35-1 C₅₁H₇₈O₃₇ 
• 1448187-18-5 (2S,4R)-N-((S)-1-(4-chlorophenyl)ethyl)-1-(3-ethoxybenzoyl)-4-hydroxypyrrolidine-2-carboxamide 
• 1448187-54-9 (2S,4R)-N-([1,1'-biphenyl]-4-ylmethyl)-1-(3-ethoxybenzoyl)-4-hydroxypyrrolidine-2-carboxamide 
• 1448187-16-3 (2S,4R)-N-(4-bromobenzyl)-1-(3-ethoxybenzoyl)-4-hydroxypyrrolidine-2-carboxamide 
• 1448189-91-0 (2S,4R)-1-(3-ethoxybenzoyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 1052703-66-8 C₁₃H₁₉NO₂ 
• 122892-59-5 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-3-ethoxy-benzamide 
• 26229-10-7 2-(3-ethoxy-phenyl)-3-phenyl-5-thioxo-4,5-dihydro-[1,3,4]thiadiazolium betaine 

Relevant articles and documents

Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are degraded and/or otherwise inhibited by bifunctional compounds of the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand that binds to the ubiquitin ligase and on the other end a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds of the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics

Small molecule choline kinase inhibitors having the following formula: are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting choline kinase enzymatic activity, and methods of treating tumors by administering an effective amount of a Formula I compound.

Design and synthesis of 99mTc-labeled benzamides dopamine D2/D3 receptor imaging agents

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