6196-39-0

Usage

Uses

Used in Organic Synthesis:
1-(2-benzylphenyl)-N,N-dimethylmethanamine is used as a synthetic intermediate for the creation of various organic compounds. Its unique structure allows for versatile reactivity, making it a valuable building block in the synthesis of complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(2-benzylphenyl)-N,N-dimethylmethanamine is used as a key component in the development of new drugs. Its chemical properties and reactivity enable the design and synthesis of novel therapeutic agents, potentially leading to the discovery of innovative treatments for various medical conditions.
Used in Chemical Intermediates:
1-(2-benzylphenyl)-N,N-dimethylmethanamine serves as a crucial chemical intermediate in the production of specialty chemicals. Its unique structural features make it a sought-after compound for further chemical modifications and the creation of advanced materials with specific properties.
Used in Research and Development:
1-(2-benzylphenyl)-N,N-dimethylmethanamine is also utilized in research and development settings, where it can be employed to study the effects of structural modifications on the properties and reactivity of chemical compounds. This knowledge can be applied to optimize the synthesis of new molecules and materials with tailored characteristics for various applications.

Upstream product

• 51954-45-1 benzhydryl-trimethyl-ammonium; iodide 
• 71964-91-5 benzhydryl-trimethyl-ammonium; bromide 
• 7510-28-3 1-(chloromethyl)-2-(phenylmethyl)benzene 
• 124-40-3 dimethyl amine 
• 40182-23-8 2-benzyl-N,N-dimethylbenzamide 
• 612-35-1 2-Benzylbenzoic acid 
• 1586-00-1 2-(benzyl)benzyl alcohol 
• 19886-78-3 1-formyl-2-[(dimethylamino)methyl]benzene 
• 22826-55-7 N,N-dimethylaminomethylstyrene 
• 91-00-9 Benzhydrylamine 
• 133302-70-2 N-methyl-N-(trimethylsilylmethyl)diphenylmethylamine 
• 547744-64-9 N-(trimethylsilylmethyl)diphenylmethylamine 
• 7732-18-5 water 
• 60-29-7 diethyl ether 

Downstream Products

• 857625-19-5 [1-(2-benzyl-phenyl)-2,2-diphenyl-ethyl]-dimethyl-amine 
• 86853-46-5 (2-(Dimethylamino)methyldiphenylmethyl)lithium 
• 98340-84-2 (2-benzyl-benzyl)-trimethyl-ammonium; iodide 

Relevant academic research and scientific papers

Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides

New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental and theoretical approaches imply that polymeric zinc hydride (ZnH2)∞ is responsible for alcohol formation, whereas dimeric zinc chloride hydride (H?Zn?Cl)2 is the key species for the production of amines.

Application of 13C NMR Spectroscopy and 13C-Labeled Benzylammonium Salts to the Study of Rearrangements of Ammonium Benzylides

Ylides generated from N-(cyanomethyl)-N,N-dimethyl-N-[α-(trimethylsilyl)benzyl]ammonium chloride (4) and fluoride anion afford the products of [1,2] shift 11 and [2,3] shift 13. Formation of product 13 shows that, in the presence of water from TBAF, rearrangements and [1,3]H shift in ylide intermediates become competitive processes. The reaction of N-benzyl-N,N-dimethyl-N-[α-(trimethylsilyl)benzyl]ammonium bromide (5) and 13C labeled (at the benzyl carbon) salt 5* gave a mixture of 10, 14, and 15 as products of [1,4], [1,2], and [2,3] rearrangement, respectively. 13C NMR spectra of products derived from salt 5* exclude [1,3]H shift in ylide 9a+-. Rearrangement of ylides generated from N-benzyl-N,N-dimethyl-N-[(dimethylphenylsilyl)methyl]ammonium bromide (6*) (enriched in 13C at benzyl carbon) and n-BuLi reveals that N,N-dimethyl-2-[(dimeth-ylphenylsilyl)methyl]benzylamine (20*) is not formed by a [1,4] shift but instead, via a [2,3] shift in silylmethylide followed by subsequent [1,4]Si and [1,2]H shift, as previously suggested in the literature. This mechanism is unique to some silyl-substituted ylides.

Synthesis of 5-alkylidene-6-(dimethylamino)methyl-1,3-cyclohexadienes from α-substituted benzyldimethylammoniomethylides

2-Substituted 5-alkylidene-6-(dimethylamino)methyl-1,3-cyclohexadienes (E)-4 and (Z)-4 were prepared by the reaction of α,4-disubstituted dimethyl[(trimethylsilyl)methyl]benzylammonium iodides 2 with cesium fluoride. Their E-isomers were stable at room temperature and could be used in the Diels-Alder reaction. Some related reactions are also described.