6196-83-4

Upstream product

• 497-38-1 Norbornan-2-on 
• 53546-37-5 α-allylbutyrophenone 
• 591-51-5 phenyllithium 
• 108-86-1 bromobenzene 
• 497-38-1 2-norbornanone 
• 6196-83-4 exo-2-phenyl-endo-bicyclo<2.2.1>heptan-2-ol 
• 4237-08-5 2-phenylnorborn-2-ene 
• 6188-97-2 2-Phenyl-2-exo-norbornylchlorid 
• 87031-08-1 2-Phenylbicyclo<3.1.1>hept-2-yl-4-nitrobenzoat 
• 497-38-1 (1S,4R)-bicyclo[2.2.1]heptan-2-one 
• 100-58-3 phenylmagnesium bromide 
• 77821-53-5 butyrophenone iminate 

Downstream Products

• 1025420-98-7 2-(2-phenylbicyclo[2.2.1]hept-2-yl)benzene-1,4-diol 
• 91911-50-1 2-Chlor-2-phenyl-norbornan 
• 6196-83-4 2-phenyl-2-endo-bicyclo<2.2.1>heptanol 

Relevant academic research and scientific papers

Electrophotochemical Ring-Opening Bromination oftert-Cycloalkanols

An electrophotochemical ring-opening bromination of unstrainedtert-cycloalkanols has been developed. This electrophotochemical method enables the oxidative transformation of cycloalkanols with 5- to 7-membered rings into synthetically useful ω-bromoketones without the use of chemical oxidants or transition-metal catalysts. Alkoxy radical species would be key intermediates in the present transformation, which generate through homolysis of the O-Br bond in hypobromite intermediates under visible light irradiation.

BICYCLO-HEPTAN-2-AMINES

The present invention provides bicyclo-heptan-2-amines that selectively bind to the sigma-2 receptor and are useful in the treatment of diseases related to the sigma-2 receptor, for example, cancer and neurological disorders.

Syntheses and In-Vitro evaluation of novel adamantane based γ-secretase inhibitors

Abnormal processing of amyloid precursor protein (APP) by β - and γ -secretases to produce excess amyloid-β-peptide is believed to contribute to the pathophysiological cascade that results in Alzheimer's disease. γ -Secretase inhibition or modulation ther

Syntheses and pharmacological evaluations of novel N-substituted bicyclo-heptane-2-amines at N-methyl-d-aspartate receptors

Several novel norcamphor (bicycloheptane)-based compounds were designed and synthesized as non-competitive N-methyl-d-aspartate receptor antagonists at the phencyclidine binding sites. The heterocyclic ring was also varied to examine piperidine, pyrrolidi

Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein

The discovery and SAR of a novel series of substituted 2,2-bisaryl-bicycloheptane inhibitors of 5-lipoxygenase activating protein (FLAP) are herein described. SAR studies have shown that 2,5-substitution on the exo-aryl group is optimal for potency. The most potent compounds in this series have an ortho-nitrogen aryl linked with a methyleneoxy as the 5-substituent and a polar group such as a urethane as the 2-substituent. One of the most potent compounds identified is the 5-benzothiazolymethoxy-2-pyridinylcarbamate derivative 2 (FLAP IC50 = 2.8 nM) which blocks 89% of ragweed induced urinary LTE4 production in dogs (at an I.V. dose of 2.5 μg/kg/min). This compound inhibits calcium ionophore stimulated LTB4 production in both human polymorphonuclear (PMN) leukocytes and human whole blood (IC50 = 2.0 and 33 nM, respectively).

DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE

The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective

The Relaxed and Spectroscopic Energies of Olefin Triplets

The relaxed energies and lifetimes of a series of olefin triplets have been determined by time-resolved photoacoustic calorimetry using a novel cell configuration which allows improved precision.The planar triplet energies of a number of olefins were meas

Norpinyl-Norbornyl Rearrangements: Resonance-Stabilized Bicyclohept-2-yl Cations

2-Phenylbicyclohept-2-yl cations (5c), generated by solvolysis of the 4-nitrobenzoate 8, undergo norpinyl-norbornyl rearrangement to a minor extent (6percent in water, 1percent in methanol).The acid-catalyzed alkoxy exchange of 2,2-dimethoxybicyc

Monoradical Rearrangements of the 1,4-Biradicals Involved in Norrish Type II Photoreactions

The photochemistry of α-allylbutyrophenone (α-AB) and that of γ-cyclopropylbutyrophenone (γ-CB) both reveal that the 1,4-biradicals generated by triplet-state γ-hydrogen abstraction undergo typical radical rearrangements in competition with their more normal type II reactions.From α-AB, 2-phenyl-2-norbornanol is formed in 1/24th the combined yield of 1-phenyl-4-penten-1-one and 1-phenyl-2-allylcyclobutanol.Its formation is explained by a 5-hexenyl-to-cyclopentylmethyl rearrangement of the 1,4-biradical, with a rate constant of 5 x 105 s-1.From γ-CB, 1-phenyl-4-hepten-1-one and 1-phenyl-4-cycloheptenol together are formed in double the yield of acetophenone.Their formation is explained by a cyclopropylcarbinyl-to-allylcarbinyl rearrangement of the 1,4-biradical, with a rate constant of 2 x 107 s-1.In both cases, the rearrangement percentages are what would be predicted if the biradicals have the same 35 - 50-ns lifetime measured for other ketones and if they rearrange with the same rate constants characteristic of monoradicals.Triplet γ-CB decays only 1.5 times faster than triplet γ-isopropylbutyrophenone, indicating that there is at most a small enhancement of the γ-hydrogen abstraction rate by cyclopropyl cojugation.Triplet α-AB decays 100 times faster than triplet butyrophenone, 99percent representing internal quenching by the β-vinyl group ( k = 8 x 108 s-1).Bicyclic oxetanes are formed in quantum yields of only 0.01.No oxetanes were isolated, only rearranged unsaturated alcohols and aldehydes.