61971-72-0

Upstream product

• 694-33-7 1,1-dichloro-2-vinyl-cyclopropane 
• 75-16-1 methylmagnesium bromide 
• 20414-46-4 2,2-dichlorocyclopropane-1-carbaldehyde 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 61971-73-1 2,2-dichlorocyclopropyl methyl ketone 
• 61971-71-9 1-(2,2-Dichloro-cyclopropyl)-1-phenyl-ethanol 
• 61971-70-8 1-(2,2-Dichloro-cyclopropyl)-1-(4-methoxy-phenyl)-ethanol 
• 62022-61-1 1-(2,2-Dichloro-cyclopropyl)-1-(4-trifluoromethyl-phenyl)-ethanol 

Relevant academic research and scientific papers

PREPARATIVE METHOD FOR THE SYNTHESIS OF 2,2-DICHLORO-1-FORMYLCYCLOPROPANE AND REACTIONS BASED ON IT

2,2-Dichloro-1-formylcyclopropane was obtained by the oxidation of (gem-dichlorocyclopropyl)methanol with pyridinium chloro- or fluorochromate.Suitable methods for the synthesis of gem-dichlorocyclopropyl-containing alcohols and ketones were developed on the basis of the product.It was shown that the proposed methods for the synthesis of cyclopropane derivatives can be used in the Julia-Johnson reaction.

A different direction of opening of the cyclopropane ring in 1-acetyl-2,2-dichlorocyclopropane and 1-acetyl-2,2-dichloro(dibromo)-3,3-dimethylcyclopropane by the action of sodium alcoholates

1-Acetyl-2,2-dichlorocyclopropane, 1-acetyl-2,2-dichloro-3,3-dimethyl-cyclopropane, and 1-acetyl-2,2-dibromo-3,3-dimethylcyclopropane react smoothly with an excess of sodium methoxide and ethoxide with cleavage of the C1-C2 bond of the cyclopropane ring and the formation of the corresponding dihydrofurans.The direction of reaction changes in the reaction of 1-acetyl-2,2-dichloro-3,3-dimethylcyclopropane with an eqiumolar amount of sodium ethoxide and of 1-acetyl-2,2-dibromo-3,3-dimethylcyclopropane with an equimolar amount of sodium ethoxide or methoxide.In this case cleavage occurs at the C1-C3 bond of the cyclopropane ring, and the corresponding alkoxy-substituted acetylenic ketone is formed as the main product.